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Showing 51–99 of 99 results

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The chromatin landscape of pathogenic transcriptional cell states in rheumatoid arthritis

The epigenetic changes underlying the heterogeneity of RA disease presentation have been the subject of intense scrutiny. In this study, the authors use multiple single-cell sequencing datasets to define ‘chromatin superstates’ in patients with RA, which associate with distinct transcription factors and disease phenotypes.

Kathryn Weinand
Saori Sakaue
Soumya Raychaudhuri
ResearchOpen Access31 May 2024
Nature Communications

Volume: 15, P: 1-25
Whole-genome sequencing of patients with rare diseases in a national health system

Whole-genome sequencing and phenotype data sharing are introduced in a national health system to streamline diagnosis and to discover coding and non-coding variants that cause rare diseases.

Ernest Turro
William J. Astle
Willem H. Ouwehand
Research24 Jun 2020
Nature

Volume: 583, P: 96-102
Assessing the utility of long-read nanopore sequencing for rapid and efficient characterization of mobile element insertions

The authors present an assessment of the utility of “third-generation” nanopore sequencing for the confirmation and characterization of mobile element insertions. and discuss how implementation of long-read nanopore sequencing can offer benefits over existing molecular approaches.

Christopher M. Watson
Laura A. Crinnion
David T. Bonthron
Research28 Sept 2020
Laboratory Investigation

Volume: 101, P: 442-449
Seeking the arthropods of Eden

W. D. Ian Rolfe
News & Views08 Nov 1990
Nature

Volume: 348, P: 112-113
Assembly and operation of the autopatcher for automated intracellular neural recording in vivo

This protocol describes how to set up and use the autopatcher, a robot that automatically obtains intracellular neural recordings from intact mammalian mouse brains.

Suhasa B Kodandaramaiah
Gregory L Holst
Edward S Boyden
Protocols03 Mar 2016
Nature Protocols

Volume: 11, P: 634-654
Voltage imaging and optogenetics reveal behaviour-dependent changes in hippocampal dynamics

A combination of improved near-infrared voltage indicators, high-speed microscopes and targeted gene expression schemes enabled simultaneous in vivo optogenetic control and recording of voltage dynamics in multiple neurons in the hippocampus of behaving mice.

Yoav Adam
Jeong J. Kim
Adam E. Cohen
Research01 May 2019
Nature

Volume: 569, P: 413-417
STAR particles for enhanced topical drug and vaccine delivery

Star-shaped, approximately 1-mm-wide ceramic particles, termed STAR particles, create micropores in the skin and, when added to topical formulations, enhance drug and vaccine delivery through the skin in mice.

Andrew R. Tadros
Andrey Romanyuk
Mark R. Prausnitz
Research09 Mar 2020
Nature Medicine

Volume: 26, P: 341-347
Potent and selective bivalent inhibitors of BET bromodomains

Structural insights demonstrating small-molecule-mediated dimerization of BRD4 bromodomains led to the development of biBET, a compound that potently inhibits BRD4–acetyl-lysine interactions by bivalent binding to tandem bromodomains.

Michael J Waring
Huawei Chen
Yi Yao
Research24 Oct 2016
Nature Chemical Biology

Volume: 12, P: 1097-1104
Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

Relatives of patients with amyotrophic lateral sclerosis have an unexpectedly high incidence of schizophrenia. Here, the authors show a genetic link between the two conditions, suggesting shared neurobiological mechanisms.

Russell L. McLaughlin
Dick Schijven
Michael C. O’Donovan
ResearchOpen Access21 Mar 2017
Nature Communications

Volume: 8, P: 1-12
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

The authors defined a roadmap for investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders. Their proof-of-concept study using the largest available common variant data sets for schizophrenia and volumes of several (mainly subcortical) brain structures did not find evidence of genetic overlap.

Barbara Franke
Jason L Stein
Patrick F Sullivan
Research01 Feb 2016
Nature Neuroscience

Volume: 19, P: 420-431
Publisher Correction: Interferon subverts an AHR–JUN axis to promote CXCL13⁺ T cells in lupus

Calvin Law
Vanessa Sue Wacleche
Deepak A. Rao
Amendments and Corrections26 Jul 2024
Nature

Volume: 632, P: E6
A high-throughput platform for stem cell niche co-cultures and downstream gene expression analysis

Magness and colleagues present a microwell-based culture system to analyse interactions between intestinal stem cells (ISCs) and Paneth cells, and show that their direct contact enhances formation of ISC-derived organoids.

Adam D. Gracz
Ian A. Williamson
Scott T. Magness
Research09 Feb 2015
Nature Cell Biology

Volume: 17, P: 340-349
Nano-structured glaucoma drainage implant safely and significantly reduces intraocular pressure in rabbits via post-operative outflow modulation

Kunal S. Parikh
Aditya Josyula
Ian Pitha
ResearchOpen Access31 Jul 2020
Scientific Reports

Volume: 10, P: 1-12
Author Correction: Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses

Jordan R. Barrett
Sandra Belij-Rammerstorfer
Dalila Zizi
Amendments and Corrections06 May 2021
Nature Medicine

Volume: 27, P: 1113
Author Correction: T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

Katie J. Ewer
Jordan R. Barrett
Elizabeth Stafford
Amendments and Corrections21 May 2021
Nature Medicine

Volume: 27, P: 1116
Implementation of a 4Pi-SMS super-resolution microscope

This protocol describes how to assemble a 4Pi single-molecule switching super-resolution microscope. Detailed instructions for beam-path alignment, testing, application to cellular samples and troubleshooting are provided.

Jingyu Wang
Edward S. Allgeyer
Joerg Bewersdorf
Protocols16 Dec 2020
Nature Protocols

Volume: 16, P: 677-727
Therapy Insight: systemic lupus erythematosus as a risk factor for cardiovascular disease

Patients with systemic lupus erythematosus are at a high risk of developing premature atherosclerosis and cardiovascular disease, but the mechanisms responsible for this are not fully understood. This review discusses traditional and lupus-specific risk factors that are likely to be involved, and outlines how risk assessments should be included in effective management of this disease.

Sahena Haque
Ian N Bruce
Reviews01 Aug 2005
Nature Clinical Practice Cardiovascular Medicine

Volume: 2, P: 423-430
Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue

Using a multi-omics approach, the authors examine the molecular drivers of sexual dimorphism in the subcutaneous adipose tissue from sedentary and endurance-trained rats. These data provide a valuable resource for adipose tissue-related research.

Gina M. Many
James A. Sanford
Jimmy Zhen
ResearchOpen Access01 May 2024
Nature Metabolism

Volume: 6, P: 963-979
Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study

Foivos Georgiadis
Sara Larivière
Matthias Kirschner
ResearchOpen Access09 Feb 2024
Molecular Psychiatry

Volume: 29, P: 1869-1881
Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Research10 Jan 2022
Nature Medicine

Volume: 28, P: 53-58
A massive 7T fMRI dataset to bridge cognitive neuroscience and artificial intelligence

The authors measured high-resolution fMRI activity from eight individuals who saw and memorized thousands of annotated natural images over 1 year. This massive dataset enables new paths of inquiry in cognitive neuroscience and artificial intelligence.

Emily J. Allen
Ghislain St-Yves
Kendrick Kay
Research16 Dec 2021
Nature Neuroscience

Volume: 25, P: 116-126
T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

A single dose of the ChAdOx1 nCoV-19 vaccine elicits antibodies and cytokine-producing T cells that might help control or prevent SARS-CoV-2 infection.

Katie J. Ewer
Jordan R. Barrett
Elizabeth Stafford
Research17 Dec 2020
Nature Medicine

Volume: 27, P: 270-278
Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Amendments and CorrectionsOpen Access12 Jan 2022
Nature Medicine

Volume: 28, P: 212
Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution

scHLApers is an analysis pipeline that quantifies single-cell expression of HLA genes using a personalized genomic reference. Mapping of HLA expression quantitative trait loci at single-cell resolution identifies dynamic effects across cell states.

Joyce B. Kang
Amber Z. Shen
Soumya Raychaudhuri
Research30 Nov 2023
Nature Genetics

Volume: 55, P: 2255-2268
Modelling the impact of forest management and CO₂-fertilisation on growth and demography in a Sitka spruce plantation

Arthur P. K. Argles
Eddy Robertson
Peter M. Cox
ResearchOpen Access18 Aug 2023
Scientific Reports

Volume: 13, P: 1-12
Early and intensive motor training to enhance neurological recovery in people with spinal cord injury: trial protocol

Lisa A. Harvey
Joanne V. Glinsky
Sachin Shetty
ResearchOpen Access06 Jul 2023
Spinal Cord

Volume: 61, P: 521-527
Robotic pendant drop: containerless liquid for μs-resolved, AI-executable XPCS

Robot-compatible liquid sample setup for a fully-automated, μs-resolved Small-angle X-ray Photon Correlation Spectroscopy (SA-XPCS) workflow that can enable autonomous designs of complex fluids.

Doga Yamac Ozgulbas
Don Jensen Jr.
Qingteng Zhang
ResearchOpen Access18 Aug 2023
Light: Science & Applications

Volume: 12, P: 1-10
Pit growth kinetics in aluminum: effects of salt loading and relative humidity

Philip J. Noell
Benjamin T. Pham
Ryan M. Katona
ResearchOpen Access29 Jul 2023
npj Materials Degradation

Volume: 7, P: 1-12
Positional cloning of a novel gene influencing asthma from Chromosome 2q14

Maxine Allen
Andrea Heinzmann
William O C M Cookson
Research19 Oct 2003
Nature Genetics

Volume: 35, P: 258-263
Characterizing the metabolic effects of the selective inhibition of gut microbial β-glucuronidases in mice

Marine P. M. Letertre
Aadra P. Bhatt
Jonathan R. Swann
ResearchOpen Access19 Oct 2022
Scientific Reports

Volume: 12, P: 1-11
Functional Magnetic Resonance Imaging of Electrical and Optogenetic Deep Brain Stimulation at the Rat Nucleus Accumbens

Daniel L. Albaugh
Andrew Salzwedel
Yen-Yu Ian Shih
ResearchOpen Access07 Sept 2016
Scientific Reports

Volume: 6, P: 1-13
Persistent near-tropical warmth on the Antarctic continent during the early Eocene epoch

A reconstruction of temperatures along the Wilkes Land coast of Antarctica during the early Eocene epoch shows that the climate supported the growth of near-tropical forests and that winters were very mild and essentially frost-free.

Jörg Pross
Lineth Contreras
Masako Yamane
Research01 Aug 2012
Nature

Volume: 488, P: 73-77
Evidence of a Steroidogenic Enzyme Gene Dose Effect on Adrenal Gene Expression in Hereditary Rabbit Congenital Adrenal Hyperplasia

Kotaro Iwamoto
Ximing Yang
Songya Pang
Research01 Nov 1994
Pediatric Research

Volume: 36, P: 660-666
Advancing the global public health agenda for NAFLD: a consensus statement

Non-alcoholic fatty liver disease (NAFLD) is a potentially serious liver disease with a substantial burden worldwide. In this Consensus Statement, a global multidisciplinary group of experts develop consensus statements and recommendations addressing a broad range of topics on NAFLD to raise awareness and spur action.

Jeffrey V. Lazarus
Henry E. Mark
Ming-Hua Zheng
Reviews27 Oct 2021
Nature Reviews Gastroenterology & Hepatology

Volume: 19, P: 60-78
Protective effect of PDE4B subtype-specific inhibition in an App knock-in mouse model for Alzheimer’s disease

Paul Armstrong
Hüseyin Güngör
Steven J. Clapcote
ResearchOpen Access23 Mar 2024
Neuropsychopharmacology

Volume: 49, P: 1559-1568
Dissemination and growth of cancer cells in metastatic sites

Ann F. Chambers
Alan C. Groom
Ian C. MacDonald
Reviews01 Aug 2002
Nature Reviews Cancer

Volume: 2, P: 563-572
Transcriptome profiles of stem-like cells from primary breast cancers allow identification of ITGA7 as a predictive marker of chemotherapy response

Noha Gwili
Stacey J. Jones
Thomas A. Hughes
ResearchOpen Access12 Jul 2021
British Journal of Cancer

Volume: 125, P: 983-993
A structure–function based approach to floc hierarchy and evidence for the non-fractal nature of natural sediment flocs

Kate L. Spencer
Jonathan A. T. Wheatland
Andrew J. Manning
ResearchOpen Access07 Jul 2021
Scientific Reports

Volume: 11, P: 1-10
Antibiotic treatment and flares of rheumatoid arthritis: a self-controlled case series study analysis using CPRD GOLD

Navraj S. Nagra
Danielle E. Robinson
Daniel Prieto-Alhambra
ResearchOpen Access20 Jun 2019
Scientific Reports

Volume: 9, P: 1-9
The global intellectual property landscape of induced pluripotent stem cell technologies

Will freedom to research and innovate be restricted as the induced pluripotent stem cell field advances toward the clinic, or are concerns premature within a rapidly changing ecosystem?

MacKenna Roberts
Ivan B Wall
David A Brindley
Comments & Opinion05 Aug 2014
Nature Biotechnology

Volume: 32, P: 742-748
Elevated ubiquitinated proteins in brain and blood of individuals with schizophrenia

Chad A. Bousman
Sandra Luza
Ian P. Everall
ResearchOpen Access19 Feb 2019
Scientific Reports

Volume: 9, P: 1-8
Genetic variation in glutamatergic genes moderates the effects of childhood adversity on brain volume and IQ in treatment-resistant schizophrenia

Suriati Mohamed Saini
Chad A. Bousman
Christos Pantelis
ResearchOpen Access14 Sept 2023
Schizophrenia

Volume: 9, P: 1-8
Paracrine cyclooxygenase-2 activity by macrophages drives colorectal adenoma progression in the Apc ^Min/+ mouse model of intestinal tumorigenesis

Mark A. Hull
Richard J. Cuthbert
P. Louise Coletta
ResearchOpen Access20 Jul 2017
Scientific Reports

Volume: 7, P: 1-14
Isolation of the protein and RNA content of active sites of transcription from mammalian cells

Transcription factories contain all three mammalian RNA polymerases, each actively transcribing a different subset of genes. This protocol describes how to isolate large factory fragments for the analysis of associated protein and RNA content.

Svitlana Melnik
Maïwen Caudron-Herger
Argyris Papantonis
Protocols25 Feb 2016
Nature Protocols

Volume: 11, P: 553-565
Elevated peripheral expression of neuregulin-1 (NRG1) mRNA isoforms in clozapine-treated schizophrenia patients

Md Shaki Mostaid
Ting Ting Lee
Chad Bousman
ResearchOpen Access11 Dec 2017
Translational Psychiatry

Volume: 7, P: 1-10
The EPIC nutrient database project (ENDB): a first attempt to standardize nutrient databases across the 10 European countries participating in the EPIC study

N Slimani
G Deharveng
E Riboli
Reviews21 Mar 2007
European Journal of Clinical Nutrition

Volume: 61, P: 1037-1056
Detection of somatic mutations in tumors using unaligned clonal sequencing data

Kate M Sutton
Laura A Crinnion
Ian M Carr
Research28 Jul 2014
Laboratory Investigation

Volume: 94, P: 1173-1183
Cas9-based enrichment and single-molecule sequencing for precise characterization of genomic duplications

Christopher M. Watson
Laura A. Crinnion
David T. Bonthron
Research04 Jul 2019
Laboratory Investigation

Volume: 100, P: 135-146
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Edward J Saunders
Tokhir Dadaev
Zsofia Kote-Jarai
ResearchOpen Access10 Mar 2016
British Journal of Cancer

Volume: 114, P: 945-952

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