In recent years, the central roles of neuronal and axonal damage, as well as axon–glial and axon–myelin interactions, in the pathogenesis and progression of multiple sclerosis (MS) have become increasingly apparent. Franklin et al. review advances in our understanding of the molecular mechanisms underlying these MS-related events, and discuss approaches towards axonal neuroprotection and repair, particularly through the regenerative process remyelination.
- Robin J. M. Franklin
- Charles ffrench-Constant
- Kenneth J. Smith
