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  • Proferroptotic activity of 7-dehydrocholesterol reductase is shown along with an unexpected prosurvival function of its substrate, 7-dehydrocholesterol, indicating a cell-intrinsic mechanism that could be used by cancer cells to protect phospholipids from oxidative damage and escape ferroptosis.

    • Florencio Porto Freitas
    • Hamed Alborzinia
    • José Pedro Friedmann Angeli
    Research
    Nature
    Volume: 626, P: 401-410