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Showing 1–8 of 8 results

Advanced filters: Author: Ifor R Williams Clear advanced filters

Acetate differentially regulates IgA reactivity to commensal bacteria

Acetate—a major gut microbial metabolite—increases the production of IgA in the colon, alters the capacity of the IgA pool to bind to specific microorganisms and alters the localization of these bacteria within the colon.

Tadashi Takeuchi
Eiji Miyauchi
Hiroshi Ohno
Research14 Jul 2021
Nature

Volume: 595, P: 560-564
Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17–producing T cell responses

Timothy L Denning
Yi-chong Wang
Bali Pulendran
Research16 Sept 2007
Nature Immunology

Volume: 8, P: 1086-1094
Role of T-cell reconstitution in HIV-1 antiretroviral therapy-induced bone loss

HIV infection causes significant bone loss, which is worsened by antiretroviral therapy (ART). Here, the authors use a mouse model to show that T cell repopulation and/or immune reactivation after ART leads to complex inflammatory effects driving bone turnover and bone loss.

Ighovwerha Ofotokun
Kehmia Titanji
M. Neale Weitzmann
Research22 Sept 2015
Nature Communications

Volume: 6, P: 1-15
The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells

Intestinal microfold (M) cells actively capture luminal antigens and move them by transcytosis to initiate immune responses. Ohno and colleagues show that the Ets transcription factor Spi-B is necessary for M-cell differentiation.

Takashi Kanaya
Koji Hase
Hiroshi Ohno
Research17 Jun 2012
Nature Immunology

Volume: 13, P: 729-736
An endogenous nanomineral chaperones luminal antigen and peptidoglycan to intestinal immune cells

Calcium phosphate nanoparticles formed naturally in the intestine aid the transport of soluble molecules from the gut lumen to immune cells of the intestinal tissue, and contribute to the immune surveillance and homeostasis of the gut.

Jonathan J. Powell
Emma Thomas-McKay
Laetitia C. Pele
Research09 Mar 2015
Nature Nanotechnology

Volume: 10, P: 361-369
Mouse model of Noonan syndrome reveals cell type– and gene dosage–dependent effects of Ptpn11 mutation

Toshiyuki Araki
M Golam Mohi
Benjamin G Neel
Research25 Jul 2004
Nature Medicine

Volume: 10, P: 849-857
FGFR3 as a therapeutic target of the small molecule inhibitor PKC412 in hematopoietic malignancies

Jing Chen
Benjamin H Lee
Dwight Gary Gilliland
Research08 Aug 2005
Oncogene

Volume: 24, P: 8259-8267
FLT3 internal tandem duplication mutations induce myeloproliferative or lymphoid disease in a transgenic mouse model

Benjamin H Lee
Ifor R Williams
Dwight Gary Gilliland
Research22 Aug 2005
Oncogene

Volume: 24, P: 7882-7892