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Showing 1–8 of 8 results
Advanced filters: Author: Ignacia Echeverria Clear advanced filters

  • A global map of human subcellular architecture yields protein complex structures, reveals protein functions, identifies assemblies with multiple localizations or cell-type specificity and decodes paediatric cancer genomes.

    • Leah V. Schaffer
    • Mengzhou Hu
    • Trey Ideker
    ResearchOpen Access
    Nature
    Volume: 642, P: 222-231

  • The authors report the cryo-EM structure of human A3G bound to HIV-1 Vif, and the hijacked cellular proteins that promote ubiquitin-mediated proteolysis, suggesting how Vif antagonizes A3G by intercepting it to prevent viral restriction.

    • Yen-Li Li
    • Caroline A. Langley
    • John D. Gross
    ResearchOpen Access
    Nature
    Volume: 615, P: 728-733

  • Polyketide synthase 13 from mycobacteria was purified endogenously ‘in action’ with wild-type substrates bound. Structures by cryo-EM define multiple states of acyl carrier proteins in the final step of mycolic acid synthesis by a key drug target.

    • Sun Kyung Kim
    • Miles Sasha Dickinson
    • Robert M. Stroud
    Research
    Nature Structural & Molecular Biology
    Volume: 30, P: 296-308

  • Crystallography and mutagenesis analyses examine how HIV-1 Nef interacts with AP2 to enable CD4 binding and downregulation and reveal the role of a Nef pocket that is also involved in downregulation of class I MHC.

    • Yonghwa Kwon
    • Robyn M. Kaake
    • Xiaofei Jia
    Research
    Nature Structural & Molecular Biology
    Volume: 27, P: 822-828

  • The structure of the yeast nuclear pore complex, determined at sub-nanometre precision using an integrative approach that combines a wide range of data, reveals details of its architecture, transport mechanism and evolutionary origins.

    • Seung Joong Kim
    • Javier Fernandez-Martinez
    • Michael P. Rout
    Research
    Nature
    Volume: 555, P: 475-482

  • Large-scale genetic datasets and deep learning approaches are being used to model the structures of proteins or protein complexes. This Review describes approaches based on coevolution, deep mutational scanning and genome-scale genetic or chemical–genetic interaction mapping and their application and integration to inform structural modelling.

    • Hannes Braberg
    • Ignacia Echeverria
    • Nevan J. Krogan
    Reviews
    Nature Reviews Genetics
    Volume: 23, P: 342-354