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Showing 1–13 of 13 results
Advanced filters: Author: Ignacio Sancho-Martinez Clear advanced filters
  • Glioma can originate from the transformation of neural progenitor cells into glioma initiating cells. Here, the authors demonstrate the use of induced pluripotent stem cells as a suitable model for generating neural progenitor cells, which can be subsequently transformed to glioma initiating cells that are able to the generate human glioma-like tumours in mice.

    • Ignacio Sancho-Martinez
    • Emmanuel Nivet
    • Juan Carlos Izpisua Belmonte
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14
  • Cellular reprogramming to a stem-cell-like state is inefficient and poorly understood, despite its biomedical potential. Detailed molecular analyses of this process are now reported, and should help to overcome these limitations.

    • Ignacio Sancho-Martinez
    • Juan Carlos Izpisua Belmonte
    News & Views
    Nature
    Volume: 493, P: 310-311
  • Human fibroblasts undergo conversion to angioblast-like progenitors and then to endothelial cells by brief exposure to pluripotency factors, which is then followed by differentiation.

    • Leo Kurian
    • Ignacio Sancho-Martinez
    • Juan Carlos Izpisua Belmonte
    Research
    Nature Methods
    Volume: 10, P: 77-83
  • Investigation of neural cells from post-mortem human brains and differentiated from patient-derived induced pluripotent stem cells shows that the LRRK2 mutation (G2019S) associated with familial and sporadic Parkinson's disease correlates with abnormalities at the nuclear envelope.

    • Guang-Hui Liu
    • Jing Qu
    • Juan Carlos Izpisua Belmonte
    Research
    Nature
    Volume: 491, P: 603-607
  • Differentiation of pluripotent cells into renal lineages has so far demonstrated limited success. Juan Carlos Ispizua Belmonte and colleagues have used defined medium conditions to obtain committed renal progenitor cells that are able to integrate into a ureteric bud in a three-dimensional culture system.

    • Yun Xia
    • Emmanuel Nivet
    • Juan Carlos Izpisua Belmonte
    Research
    Nature Cell Biology
    Volume: 15, P: 1507-1515
  • Lineage conversion has recently attracted increasing attention as a potential alternative to the directed differentiation of pluripotent cells to obtain cells of a given lineage. Different means allowing for cell identity switch have been reported. Lineage conversion relied initially on the discovery of specific transcription factors generally enriched and characteristic of the target cell, and their forced expression in cells of a different fate. This approach has been successful in various cases, from cells of the hematopoietic systems to neurons and cardiomyocytes. Furthermore, recent reports have suggested the possibility of establishing a general lineage conversion approach bypassing pluripotency. This requires a first phase of epigenetic erasure achieved by short overexpression of the factors used to reprogram cells to a pluripotent state (such as a combination of Sox2, Klf4, c-Myc and Oct4), followed by exposure to specific developmental cues. Here we present these different direct conversion methodologies and discuss their potential as alternatives to using induced pluripotent stem cells and differentiation protocols to generate cell populations of a given fate.

    • Ignacio Sancho-Martinez
    • Sung Hee Baek
    • Juan Carlos Izpisua Belmonte
    Reviews
    Nature Cell Biology
    Volume: 14, P: 892-899
  • Gene-editing technologies and patient-specific induced pluripotent stem cells (iPSCs) may represent an unprecedented opportunity for merging the stem cell and traditional gene therapy fields to fulfill the promises of regenerative medicine.

    • Guang-Hui Liu
    • Ignacio Sancho-Martinez
    • Juan Carlos Izpisua Belmonte
    Research Highlights
    Cell Research
    Volume: 22, P: 283-284