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Showing 1–3 of 3 results
Advanced filters: Author: Igor Baars Clear advanced filters

  • A label-free, DNA-based proximity ligation assay that uses ligatable staple pairs enables the longitudinal quantification of DNA origami structural stability dynamics in vivo, with single-helix resolution for both wireframe and lattice designs.

    • Yang Wang
    • Iris Rocamonde-Lago
    • Björn Högberg
    ResearchOpen Access
    Nature Nanotechnology
    Volume: 21, P: 268-276

  • Here the authors present a pH-sensitive DNA origami nanoswitch that hides ligands for death receptors and displays them as a cytotoxic hexagonal pattern in acidic tumour microenvironments. This reduces tumour growth in a murine model of breast cancer with minimal on-target, off-tumour toxicity.

    • Yang Wang
    • Igor Baars
    • Björn Högberg
    ResearchOpen Access
    Nature Nanotechnology
    Volume: 19, P: 1366-1374

  • DNA microscopy reconstructs the spatial organization of a sample from a neighborhood graph. In this work, MinIPath efficiently corrects errors from these graphs that distort the reconstruction, both in simulated and experimental data.

    • Alexander Kloosterman
    • Igor Baars
    • Björn Högberg
    ResearchOpen Access
    Nature Computational Science
    Volume: 4, P: 119-127