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Showing 1–7 of 7 results
Advanced filters: Author: Ilan Gronau Clear advanced filters

  • Levantine Phoenicians made little genetic contribution to Punic settlements in the central and western Mediterranean between the sixth and second centuries bce; instead, the Punic people derived most of their ancestry from a genetic profile similar to that of Sicily and the Aegean, with notable contributions from North Africa as well.

    • Harald Ringbauer
    • Ayelet Salman-Minkov
    • David Reich
    Research
    Nature
    Volume: 643, P: 139-147

  • It is known that there was gene flow from Neanderthals to modern humans around 50,000 years ago; now, analysis of a Neanderthal genome from the Altai Mountains in Siberia reveals evidence of gene flow 100,000 years ago in the other direction—from early modern humans to Neanderthals.

    • Martin Kuhlwilm
    • Ilan Gronau
    • Sergi Castellano
    Research
    Nature
    Volume: 530, P: 429-433

  • Adam Siepel and colleagues estimate key parameters for ancient human demography using a Bayesian analysis of the whole-genome sequences of six individuals from diverse populations. They present new methods for coalescent-based inference of demographic parameters as well as a custom pipeline for genotype inference.

    • Ilan Gronau
    • Melissa J Hubisz
    • Adam Siepel
    Research
    Nature Genetics
    Volume: 43, P: 1031-1034

  • Adam Siepel and colleagues develop a statistical method, fitCons, which combines comparative and functional genomic data to estimate the probability that a point mutation will influence fitness. They generate fitCons scores for three human cell types from ENCODE data sets and demonstrate improved prediction power for cis regulatory elements in comparison to conventional conservation-based scores.

    • Brad Gulko
    • Melissa J Hubisz
    • Adam Siepel
    Research
    Nature Genetics
    Volume: 47, P: 276-283

  • Adam Siepel and colleagues find that natural selection has exerted a significant influence on transcription factor binding sites in the human lineage using a new probabilistic method, INSIGHT. They analyzed whole-genome sequences from 54 individuals, as well as from several non-human primates, combined with chromatin immunoprecipitation and sequencing data sets to identify transcription factor binding sites and evidence of selection.

    • Leonardo Arbiza
    • Ilan Gronau
    • Adam Siepel
    Research
    Nature Genetics
    Volume: 45, P: 723-729