Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–10 of 10 results
Advanced filters: Author: Ilian Atanassov Clear advanced filters

  • Here, using long-read RNA sequencing, SILAC proteomics, and cryo-EM, the authors show that loss of mitochondrial methylation impairs rRNA processing and ribosome maturation, leading to unprocessed rRNA accumulation and defective monosome assembly.

    • Ruth I. C. Glasgow
    • Vivek Singh
    • Anna Wredenberg
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Multiple GTP-binding proteins (GTPBPs) aid ribosome maturation. Here, authors pinpoint GTPBP8’s involvement in human mitoribosome maturation, demonstrating its specific binding to mitoribosomal large subunit RNA, which is necessary for ribosome assembly and protein synthesis.

    • Miriam Cipullo
    • Genís Valentín Gesé
    • Joanna Rorbach
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Structural analysis of several small mitoribosomal subunit intermediates reveals a sequential mechanism of biogenesis, and how assembly links to initiation to form active mitoribosomes.

    • Yuzuru Itoh
    • Anas Khawaja
    • Alexey Amunts
    ResearchOpen Access
    Nature
    Volume: 606, P: 603-608

  • The glutamine fructose-6-phosphate amidotransferase 1 (GFAT-1) is the rate-limiting enzyme in the hexosamine pathway producing uridine 5’-diphospho-N-acetyl-D-glucosamine (UDP-GlcNAc), an essential glycosylation precursor. Here, the authors dissect the mechanisms of GFAT-1 regulation by protein kinase A (PKA)-mediated phosphorylation.

    • Sabine Ruegenberg
    • Felix A. M. C. Mayr
    • Martin S. Denzel
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • The mammalian mitochondrial genome contains two noncanonical stop codons, AGA and AGG. Here, the authors show that mtRF1, a mitochondrial protein of unknown function, triggers translation termination at AGA or AGG, placing mtRF1 among mitochondrial translation factors.

    • Annika Krüger
    • Cristina Remes
    • Joanna Rorbach
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Inhibitors of mitochondrial transcription that target human mitochondrial RNA polymerase provide a chemical biology tool for studying the role of mitochondrial DNA expression in a wide range of pathologies.

    • Nina A. Bonekamp
    • Bradley Peter
    • Nils-Göran Larsson
    Research
    Nature
    Volume: 588, P: 712-716

  • It has been debated whether premature ageing in mitochondrial DNA mutator mice is driven by point mutations or deletions of mtDNA. Matic et al generate Mgme1 knockout mice and show here that these mice have tissue-specific replication stalling and accumulate deleted mtDNA, without developing progeria.

    • Stanka Matic
    • Min Jiang
    • Dusanka Milenkovic
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • ADP-ribosylation is a post-translational protein modification that regulates numerous cellular pathways. An approach involving histone purification, partial filter-aided digestion and ETD mass spectrometry reveals that serine residues in histone proteins are ADP-ribosylated.

    • Orsolya Leidecker
    • Juan José Bonfiglio
    • Ivan Matic
    Research
    Nature Chemical Biology
    Volume: 12, P: 998-1000

  • Tharyan et al. identify NFYB-1 as a regulator of mitochondrial function that represses lysosomal prosaposin. The NFYB-1–prosaposin signalling axis coordinates lysosomal-to-mitochondria signalling via cardiolipin to enhance cellular mitochondrial function and longevity in C. elegans.

    • Rebecca George Tharyan
    • Andrea Annibal
    • Adam Antebi
    Research
    Nature Metabolism
    Volume: 2, P: 387-396