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Showing 1–9 of 9 results
Advanced filters: Author: Ilsa I Rovira Clear advanced filters

  • Mice deficient in the Polycomb repressor Bmi1 have a shortened lifespan and develop numerous abnormalities including defects in stem cell self-renewal and thymocyte maturation. Here it is demonstrated that cells derived from Bmi1−/− mice also show a marked elevation in the intracellular levels of reactive oxygen species, corresponding to the derepression of previously identified Polycomb target genes and sufficient to engage the DNA damage response pathway.

    • Jie Liu
    • Liu Cao
    • Toren Finkel
    Research
    Nature
    Volume: 459, P: 387-392

  • Here it is shown that the NAD-dependent deacetylase SIRT2 is an essential component of necrosis, and that mouse hearts that do not contain SIRT2 or that are treated with a pharmacological inhibitor of SIRT2 are largely protected from ischaemic injury.

    • Nisha Narayan
    • In Hye Lee
    • Toren Finkel
    Research
    Nature
    Volume: 492, P: 199-204

  • Until the recent discovery of the mitochondrial calcium uniporter (MCU), the effect of increases in mitochondrial calcium levels could not be tested in vivo. Finkel and colleagues have knocked out the gene coding for MCU in adult mice, and show that MCU is required for transport of calcium into the mitochondria. They also show that, in its absence, the function of skeletal muscle is altered; however, surprisingly, no effects are observed on the sensitivity to cell-death-inducing agents.

    • Xin Pan
    • Jie Liu
    • Toren Finkel
    Research
    Nature Cell Biology
    Volume: 15, P: 1464-1472

  • The tumour suppressor BRCA1 is mutated in familial breast and ovarian cancer. Now, Shuklaet al.demonstrate that mice lacking BRCA1 in cardiomyocytes are more sensitive to ischaemia than control mice, and that BRCA1 is elevated in human tissues exposed to ischaemia, suggesting a cardioprotective role for BRCA1.

    • Praphulla C. Shukla
    • Krishna K. Singh
    • Subodh Verma
    ResearchOpen Access
    Nature Communications
    Volume: 2, P: 1-11

  • In the process of autophagy, cellular constituents are degraded and recycled. Toren Finkel and his colleagues show that this process also regulates the secretion of a key blood-clotting protein by endothelial cells, such that transient inhibition of autophagy might be therapeutically useful for treating thrombotic disorders.

    • Takehiro Torisu
    • Kumiko Torisu
    • Toren Finkel
    Research
    Nature Medicine
    Volume: 19, P: 1281-1287