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Showing 1–4 of 4 results
Advanced filters: Author: Ilya Kolb Clear advanced filters

  • Using large-scale screening and structure-guided mutagenesis, fast and sensitive GCaMP sensors are developed and optimized with improved kinetics without compromising sensitivity or brightness.

    • Yan Zhang
    • Márton Rózsa
    • Loren L. Looger
    ResearchOpen Access
    Nature
    Volume: 615, P: 884-891

  • The genetically encoded GABA sensor iGABASnFR allows visualizing GABA signaling in vivo. Its application is demonstrated in mouse slices, in the awake mouse and in behaving zebrafish.

    • Jonathan S. Marvin
    • Yoshiteru Shimoda
    • Loren L. Looger
    Research
    Nature Methods
    Volume: 16, P: 763-770

  • Genetically encoded voltage indicators (GEVIs) allow visualisation of fast action potentials in neurons but most are bright at rest and dimmer during an action potential. Here, the authors engineer electrochromic FRET GEVIs with fast, bright and positive-going fluorescence signals for in vivo imaging.

    • Ahmed S. Abdelfattah
    • Rosario Valenti
    • Eric R. Schreiter
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-8

  • Results for the final phase of the 1000 Genomes Project are presented including whole-genome sequencing, targeted exome sequencing, and genotyping on high-density SNP arrays for 2,504 individuals across 26 populations, providing a global reference data set to support biomedical genetics.

    • Adam Auton
    • Gonçalo R. Abecasis
    • Gonçalo R. Abecasis
    ResearchOpen Access
    Nature
    Volume: 526, P: 68-74