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Showing 1–4 of 4 results
Advanced filters: Author: Im-Sook Song Clear advanced filters

  • Acid sphingomyelinase (ASM) is a sphingolipid metabolizing enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide, and previous work has shown it is upregulated in models of Alzheimer’s disease. Here the authors demonstrate in a mouse model of Alzheimer’s disease that antibody-based immunotherapy targeting plasma ASM resulted in attenuated neuropathological features by suppressing pathogenic Th17 cells.

    • Byung Jo Choi
    • Min Hee Park
    • Jae-sung Bae
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Neuronal sphingosine kinase 1 (SphK1) acetylates COX2 which is needed for microglial phagocytosis activity, and release of pro-resolving mediators (SPMs) from neurons. Here the authors examine how SphK1-mediates COX2 acetylation, and how this leads to increased secretion of SPMs from neurons in the context of Alzheimer’s disease models.

    • Ju Youn Lee
    • Seung Hoon Han
    • Jae-sung Bae
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-19

  • Sphingosine kinase (SphK) converts sphingosine into lipids, and is implicated in inflammation. Here the authors show that SphK1 functions as an acetyltransferase, regulates microglial phagocytosis and is reduced in a model of Alzheimer’s Disease, such that its restoration ameliorates pathology

    • Ju Youn Lee
    • Seung Hoon Han
    • Hee Kyung Jin
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14