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Advanced filters: Author: Imtiyaz Yaseen Clear advanced filters

Mycobacteria modulate host epigenetic machinery by Rv1988 methylation of a non-tail arginine of histone H3

Epigenetic modulation of hosts by pathogenic bacteria is underexplored. Here, Yaseen et al. show that protein Rv1988 from Mycobacterium tuberculosisenhances microbial survival by methylating histone H3 in the host cell nucleus and thus altering host gene expression.

Imtiyaz Yaseen
Prabhjot Kaur
Sanjeev Khosla
Research16 Nov 2015
Nature Communications

Volume: 6, P: 1-13
Proteasome-dependent truncation of the negative heterochromatin regulator Epe1 mediates antifungal resistance

Here, the authors find that histone demethylase Epe1-mediated stress resistance is regulated by proteasome-dependent truncation, allowing heterochromatin to reprogram gene expression that confers antifungal resistance to some fission yeast cells in the population.

Imtiyaz Yaseen
Sharon A. White
Robin C. Allshire
Research25 Jul 2022
Nature Structural & Molecular Biology

Volume: 29, P: 745-758
Epigenetic gene silencing by heterochromatin primes fungal resistance

Fission yeast grown in sublethal levels of caffeine develop heterochromatin-dependent epimutations conferring unstable heritable gene silencing that conveys resistance to caffeine, while remaining genetically wild type.

Sito Torres-Garcia
Imtiyaz Yaseen
Robin C. Allshire
Research09 Sept 2020
Nature

Volume: 585, P: 453-458

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