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Showing 1–4 of 4 results

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Lateral hypothalamic proenkephalin neurons drive threat-induced overeating associated with a negative emotional state

Stress-induced negative emotion results in comfort eating. Here authors identify the enkephalinergic LH circuit and its interaction with stress hormone, corticosterone, as crucial players in the threat-induced emotional eating for palatable foods.

In-Jee You
Yeeun Bae
Sora Shin
ResearchOpen Access28 Oct 2023
Nature Communications

Volume: 14, P: 1-20
Early adversity promotes binge-like eating habits by remodeling a leptin-responsive lateral hypothalamus–brainstem pathway

Early-life trauma is a risk factor for binge eating and obesity later in life. Shin et al. identify a hypothalamus–brainstem circuit in mice that underlies the early-life trauma-induced binge-like consumption of high-fat diet and obesity-prone characteristics.

Sora Shin
In-Jee You
Byung Kook Lim
ResearchOpen Access12 Dec 2022
Nature Neuroscience

Volume: 26, P: 79-91
Optineurin-facilitated axonal mitochondria delivery promotes neuroprotection and axon regeneration

Optineurin is linked to ALS and glaucoma, but the mechanism is unknown. Here, the authors show that optineurin mutation causes deficits in axonal mitochondria transport and neurodegeneration, enhancing of which achieves axon protection and regeneration.

Dong Liu
Hannah C. Webber
Yang Hu
ResearchOpen Access20 Feb 2025
Nature Communications

Volume: 16, P: 1-23
5-HT_1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking

In-Jee You
Sherie R Wright
Sunmee Wee
Research01 Sept 2015
Neuropsychopharmacology

Volume: 41, P: 1210-1222