Linterman and colleagues examine germinal center formation in older individuals. They find that aged TFH cells have dysregulated CXCR4 expression, which causes spatial mislocalization of these cells in germinal centers, impairing their ability to provide help to B cells and to promote antibody production.
- Alyssa Silva-Cayetano
- Sigrid Fra-Bido
- Michelle A. Linterman
