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Showing 1–3 of 3 results
Advanced filters: Author: Ines Desanlis Clear advanced filters

  • Pioneer factors direct cell fate through switching inaccessible chromatin to an accessible state at specific target enhancers. Here the authors show that HOX13 transcription factors have a pioneer activity which is required for the proper implementation of the distal limb developmental program.

    • Ines Desanlis
    • Yacine Kherdjemil
    • Marie Kmita
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Myoblast fusion is essential for development of multinucleated myofibers. Here, the authors show that ablation of Elmo 1 and Elmo2 impairs myoblast fusion in mice, and that expression of an open conformation of Elmo2 promotes muscle regeneration and improves the phenotype of Dysferlin-null dystrophic mice.

    • Viviane Tran
    • Sarah Nahlé
    • Jean-François Côté
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Mice knockdown for Angiopoietin-like 2 (Angptl2) exhibit spontaneous aortic valve stenosis associated with a decrease in Notch signalling and an imbalance in cell apoptosis, senescence and proliferation during embryonic valve remodelling stage.

    • Pauline Labbé
    • Victoria Munoz Goyette
    • Éric Thorin
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-18