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Showing 1–2 of 2 results
Advanced filters: Author: Ines Heiland Clear advanced filters
  • By increasing NAD+ consumption in various organelles, mitochondria are revealed to act as buffers that help maintain subcellular NAD+ levels. At the same time, cells are found to be particularly sensitive to a decline in NAD+ levels originating from mitochondria themselves.

    • Lena E. Høyland
    • Magali R. VanLinden
    • Mathias Ziegler
    Research
    Nature Metabolism
    Volume: 6, P: 2319-2337
  • Nematodes define a new role for sirtuins in lifespan extension, in which the sirtuin product nicotinamide is converted to a substrate for aldehyde oxidase; turnover of this enzyme generates hydrogen peroxide, causing upregulation of defense mechanisms that promote longevity.

    • Kathrin Schmeisser
    • Johannes Mansfeld
    • Michael Ristow
    Research
    Nature Chemical Biology
    Volume: 9, P: 693-700