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Showing 1–10 of 10 results
Advanced filters: Author: Ines Hellmann Clear advanced filters

  • There has been a rapid rise in single cell RNA-seq methods and associated pipelines. Here the authors use simulated data to systematically evaluate the performance of 3000 possible pipelines to derive recommendations for data processing and analysis of different types of scRNA-seq experiments.

    • Beate Vieth
    • Swati Parekh
    • Ines Hellmann
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Sequencing of the bonobo genome shows that more than three per cent of the human genome is more closely related to either the bonobo genome or the chimpanzee genome than those genomes are to each other.

    • Kay Prüfer
    • Kasper Munch
    • Svante Pääbo
    ResearchOpen Access
    Nature
    Volume: 486, P: 527-531

  • Single-cell RNA-barcoding and sequencing is an efficient, genome-wide method to characterize cellular identities. Here the authors systematically evaluate the protocol and develop molecular crowding SCRB-seq with improved sensitivity and cost-efficiency.

    • Johannes W. Bagnoli
    • Christoph Ziegenhain
    • Wolfgang Enard
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-8

  • Identifying regions of the human genome that have been subject to selection is key to understanding our evolution, and provides insights into the genetic basis of disease. However, important caveats require consideration when interpreting the results of attempts to identify selected regions.

    • Rasmus Nielsen
    • Ines Hellmann
    • Andrew G. Clark
    Reviews
    Nature Reviews Genetics
    Volume: 8, P: 857-868

  • A complete genome sequence is presented of a female Neanderthal from Siberia, providing information about interbreeding between close relatives and uncovering gene flow events among Neanderthals, Denisovans and early modern humans, as well as establishing substitutions that became fixed in modern humans after their separation from the ancestors of Neanderthals and Denisovans.

    • Kay Prüfer
    • Fernando Racimo
    • Svante Pääbo
    Research
    Nature
    Volume: 505, P: 43-49