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Showing 1–8 of 8 results

Advanced filters: Author: Ing Swie Goping Clear advanced filters

The non-cytotoxic small molecule NPB does not inhibit BAD phosphorylation and forms colloidal aggregates

John Maringa Githaka
Tomás Gutiérrez
Ing Swie Goping
ResearchOpen Access10 May 2025
Communications Medicine

Volume: 5, P: 1-5
BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models

Preventing phosphorylation of BAD (3SA) in mouse models and human cells inhibits mammary gland development, acting by disrupting 4E-BP1- mediated translation and affecting focal adhesion/protrusion stability, cell migration and ductal tubulogenesis.

John Maringa Githaka
Namita Tripathi
Ing Swie Goping
ResearchOpen Access19 May 2021
Nature Communications

Volume: 12, P: 1-18
Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells

Natural killer cells and cytotoxic T lymphocytes kill targeted cells by releasing granzymes and perforin. Lieberman and colleagues show that these lethal molecules first accumulate in endocytic vesicles, where perforin generates pores that leak granzymes into the cytosol.

Jerome Thiery
Dennis Keefe
Judy Lieberman
Research19 Jun 2011
Nature Immunology

Volume: 12, P: 770-777
Multiple anti-tumor programs are activated by blocking BAD phosphorylation

John Maringa Githaka
Raven Kirschenman
Ing Swie Goping
Research02 May 2025
Oncogene

Volume: 44, P: 2530-2546
BIK drives an aggressive breast cancer phenotype through sublethal apoptosis and predicts poor prognosis of ER-positive breast cancer

Vrajesh Pandya
John Maringa Githaka
Ing Swie Goping
ResearchOpen Access11 Jun 2020
Cell Death & Disease

Volume: 11, P: 1-19
Non-canonical BAD activity regulates breast cancer cell and tumor growth via 14-3-3 binding and mitochondrial metabolism

Jasdeep Mann
John Maringa Githaka
Ing Swie Goping
ResearchOpen Access11 Jan 2019
Oncogene

Volume: 38, P: 3325-3339
BAD sensitizes breast cancer cells to docetaxel with increased mitotic arrest and necroptosis

Jasdeep Mann
Ning Yang
Ing Swie Goping
ResearchOpen Access15 Jan 2020
Scientific Reports

Volume: 10, P: 1-11
Photo-activation of the delocalized lipophilic cation D112 potentiates cancer selective ROS production and apoptosis

Ning Yang
Michael Weinfeld
Ing Swie Goping
ResearchOpen Access02 Feb 2017
Cell Death & Disease

Volume: 8, P: e2587