Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–7 of 7 results
Advanced filters: Author: Ingo Willuhn Clear advanced filters

  • This research identifies local field potential markers associated with obsessive–compulsive disorder symptoms in patients during provocation. Key findings reveal increased delta and alpha power in specific brain regions, correlating with symptom severity and suggesting potential biomarkers for targeted interventions.

    • Tara Arbab
    • Melisse N. Bais
    • Damiaan Denys
    ResearchOpen Access
    Nature Mental Health
    Volume: 3, P: 889-898

  • The mechanisms of deep-brain stimulation for psychiatric disorders remain insufficiently understood. Here, the authors identified recruitment of cortico-striatal regions, in particular the medial orbitofrontal cortex, as a mechanism to treat compulsivity.

    • Bastijn J. G. van den Boom
    • Alfredo Elhazaz-Fernandez
    • Ingo Willuhn
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • The authors measured striatal dopamine (DA) release in vivo using fast-scan cyclic voltammetry in a model involving escalating self-administration of cocaine in rats. Phasic DA release in ventromedial striatum was negatively correlated with escalation of cocaine intake. The DA precursor L-DOPA restored phasic DA release and reversed escalation of cocaine intake.

    • Ingo Willuhn
    • Lauren M Burgeno
    • Paul E M Phillips
    Research
    Nature Neuroscience
    Volume: 17, P: 704-709

  • A chronically implanted biocompatible electrochemical microsensor allows long-term recording of subsecond dopamine dynamics in vivo. The microsensor can reliably detect behaviorally evoked dopamine release from dopamine neurons in the brain over a period of months in rats.

    • Jeremy J Clark
    • Stefan G Sandberg
    • Paul E M Phillips
    Research
    Nature Methods
    Volume: 7, P: 126-129

  • Humans and animals readily learn to associate neutral cues paired with rewards, but the exact role that dopamine release has in this learning is controversial. Using previously established rat strains selectively bred for many generations to have greater or lesser propensity to assign value to learned cues, this study uses cyclic voltammetry to measure dopamine signals in the different strains and also examines the effect of blocking dopamine. It is concluded that dopamine selectively mediates motivational, rather than predictive, aspects of the cues.

    • Shelly B. Flagel
    • Jeremy J. Clark
    • Huda Akil
    Research
    Nature
    Volume: 469, P: 53-57

  • Aberrant increased dopaminergic function results in impaired value-based decision making. Here the authors report pathway-specific effects of VTA activation on distinct aspects of flexible value-based decisions in rats.

    • Jeroen P. H. Verharen
    • Johannes W. de Jong
    • Louk J. M. J. Vanderschuren
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15