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Showing 1–5 of 5 results
Advanced filters: Author: Ingo Wohlgemuth Clear advanced filters

  • Mutations in elongation factor G protect bacteria from aminoglycoside antibiotics through unknown mechanisms. Here, the authors show that the mutations selectively slow the movement of antibiotic-bound ribosomes along mRNA, which prevents error-prone protein synthesis and thus membrane damage and antibiotic uptake.

    • Nilanjan Ghosh Dastidar
    • Nicola S. Freyer
    • Ingo Wohlgemuth
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • The ribosomal stalk L12 is the only multi-copy protein in the ribosome and is essential for translation. Here Davydov et al.use a bioinformatics and mass spectrometry approach to study the evolution of L12 in bacterial ribosomes and predict its stoichiometry in a wide range of species.

    • Iakov I. Davydov
    • Ingo Wohlgemuth
    • Marina V. Rodnina
    Research
    Nature Communications
    Volume: 4, P: 1-10

  • Aminoglycoside antibiotics target the ribosome and induce misreading, yet which translation errors induce bacterial cell death is unclear. Here authors use quantitative mass spectrometry and show that bactericidal aminoglycosides induce clusters of errors in full-length proteins in vivo with as many as four amino acid substitutions in a row.

    • Ingo Wohlgemuth
    • Raffaella Garofalo
    • Marina V. Rodnina
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Ribosomes tend to stall during the translation of consecutive proline residues, which can be rescued by the co-translational factor EF-P. Here the authors identify a structural element of tRNAProresponsible for specific recognition by EF-P and stimulation of Pro-Pro peptide bond formation.

    • Takayuki Katoh
    • Ingo Wohlgemuth
    • Hiroaki Suga
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • This Review examines the diverse strategies utilized by naturally occurring antibiotics and suggests how they have provided, and will in future provide, inspiration for the design of novel antibiotics.

    • Kim Lewis
    • Richard E. Lee
    • Ingo Wohlgemuth
    Reviews
    Nature
    Volume: 632, P: 39-49