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Showing 1–3 of 3 results
Advanced filters: Author: Ingrun Alseth Clear advanced filters

  • Bacterial endonuclease V enzymes are characterized as DNA repair proteins. Here the authors show that human endonuclease V is an inosine-specific ribonuclease, indicating a role for this enzyme in normal RNA metabolism rather than DNA repair.

    • Erik Sebastian Vik
    • Meh Sameen Nawaz
    • Ingrun Alseth
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-7

  • Endonuclease V can initiate the repair of deaminated purine bases by recognizing them and hydrolyzing the second phosphodiester bond on their 3′ side. Now the crystal structures of endonuclease V in complex with its substrate and its product reveal a wedge motif acting as a minor groove–damage sensor and a pocket to recognize the lesion; the enzyme remains tightly bound to the 5′ phosphate product, perhaps to hand it over to downstream repair factors.

    • Bjørn Dalhus
    • Andrew S Arvai
    • Magnar Bjørås
    Research
    Nature Structural & Molecular Biology
    Volume: 16, P: 138-143