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Showing 1–2 of 2 results
Advanced filters: Author: Inmaculada M González-González Clear advanced filters

  • Phosphorylation and SUMOylation of the kainate receptor (KAR) subunit GluK2 have both individually been shown to regulate KAR surface expression. Here the authors find that KAR synaptic plasticity and transmission are regulated by the dynamic interaction of GluK2 phosphorylation and SUMOylation.

    • Sophie E L Chamberlain
    • Inmaculada M González-González
    • Jack R Mellor
    Research
    Nature Neuroscience
    Volume: 15, P: 845-852

  • The authors show that activation of GluK2-containing kainate receptors on hippocampal neurons, by either agonist application or high-frequency synaptic stimulation, leads to a new form of NMDA-receptor-independent LTP. Induction of this form of plasticity requires the metabotropic action of postsynaptic kainate receptors, which triggers spine growth and potentiation of AMPA-receptor-mediated transmission.

    • Milos M Petrovic
    • Silvia Viana da Silva
    • Jeremy M Henley
    Research
    Nature Neuroscience
    Volume: 20, P: 529-539