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Showing 1–5 of 5 results
Advanced filters: Author: Inmaculada Martínez-Reyes Clear advanced filters

  • Mitochondrial metabolites contribute to more than biosynthesis, and it is clear that they influence multiple cellular functions in a variety of ways. Here, Martínez-Reyes and Chandel review key metabolites and describe their effects on processes involved in physiology and disease including chromatin dynamics, immunity, and hypoxia.

    • Inmaculada Martínez-Reyes
    • Navdeep S. Chandel
    ReviewsOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Oxidation of ubiquinol by the mitochondrial electron transfer chain drives tumour growth by maintaining the function of the oxidative Krebs cycle and de novo pyrimidine synthesis.

    • Inmaculada Martínez-Reyes
    • Luzivette Robles Cardona
    • Navdeep S. Chandel
    Research
    Nature
    Volume: 585, P: 288-292

  • A positive-selection CRISPR screen with the pro-oxidant paraquat (PQ) uncovers three genes mediating PQ-induced cell death: POR is the source of PQ-mediated reactive oxygen species (ROS) generation, and ATP7A and SLC45A4 promote oxidant-dependent cell death.

    • Colleen R Reczek
    • Kıvanç Birsoy
    • Navdeep S Chandel
    Research
    Nature Chemical Biology
    Volume: 13, P: 1274-1279

  • Specific ablation of mitochondrial complex III subunits in Treg cells in mice results in inflammatory disease, altered Treg gene expression and defective Treg function, indicating a key functional role for mitochondrial complex III in Treg cells.

    • Samuel E. Weinberg
    • Benjamin D. Singer
    • Navdeep S. Chandel
    Research
    Nature
    Volume: 565, P: 495-499

  • This Perspective discusses the main themes in cancer metabolism research that are currently under investigation in the context of in vivo tumour metabolism, specifically emphasizing emerging aspects and questions that remain unanswered.

    • Inmaculada Martínez-Reyes
    • Navdeep S. Chandel
    Reviews
    Nature Reviews Cancer
    Volume: 21, P: 669-680