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Showing 1–5 of 5 results
Advanced filters: Author: Ioannis Manolaridis Clear advanced filters

  • The structure of human ABCG2 bound to an inhibitory antibody using cryo-electron microscopy, representing the first high-resolution structural data of a human multidrug transporter.

    • Nicholas M. I. Taylor
    • Ioannis Manolaridis
    • Kaspar P. Locher
    Research
    Nature
    Volume: 546, P: 504-509

  • Cryo-EM structures of human ABCG2 bound to synthetic derivatives of inhibitor Ko143 or the multidrug resistance modulator tariquidar together with insight into the structure–activity relationship of the Ko143 scaffold provide a basis for the design of novel ABCG2 inhibitors.

    • Scott M. Jackson
    • Ioannis Manolaridis
    • Kaspar P. Locher
    Research
    Nature Structural & Molecular Biology
    Volume: 25, P: 333-340

  • ABCG2 is a transporter contributing to multidrug resistance of cancer cells. Here, structures of human ABCG2 under turnover conditions reveal distinct conformational states, provide insight into the transport cycle and suggest a mechanism of discrimination between substrates and inhibitors.

    • Qin Yu
    • Dongchun Ni
    • Kaspar P. Locher
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12