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Showing 1–3 of 3 results
Advanced filters: Author: Irena Kadiu Clear advanced filters

  • Using single-nucleus RNA sequencing data from patients with sporadic amyotrophic lateral sclerosis (ALS) cortices, the authors find that higher expression of ALS risk genes is accompanied by upregulation of stress responses in groups of extratelencephalic neurons. Analyses of glial nuclei revealed a downregulation of myelination genes in oligodendrocytes and upregulation of reactive state genes in microglia.

    • Francesco Limone
    • Daniel A. Mordes
    • Kevin Eggan
    ResearchOpen Access
    Nature Aging
    Volume: 4, P: 984-997

  • Reduced abundance of immune-stimulating gut bacteria ameliorated the inflammatory and autoimmune phenotypes of mice with mutations in C9orf72, which in the human orthologue are linked to amyotrophic lateral sclerosis and frontotemporal dementia.

    • Aaron Burberry
    • Michael F. Wells
    • Kevin Eggan
    Research
    Nature
    Volume: 582, P: 89-94

  • The identification of new drug targets is highly challenging, particularly for diseases of the brain. This study describes a general computational gene regulatory framework called CRAFT for drug target discovery, and the authors use CRAFT to identify the microglial membrane receptor Csf1R as a potential therapeutic target for epilepsy.

    • Prashant K. Srivastava
    • Jonathan van Eyll
    • Michael R. Johnson
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15