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Regulation of cytokine signaling through direct interaction between cytokine receptors and the ATG16L1 WD40 domain

The WD40 domain of ATG16L1 is thought to be involved in non-canonical autophagy. Here the authors screen peptide libraries and identify interactions between this domain and the IL-2Rγ and IL-10RB receptors, indicating endosomal regulation of cytokine signalling by non-canonical autophagy.

Inmaculada Serramito-Gómez
Emilio Boada-Romero
Felipe X. Pimentel-Muiños
ResearchOpen Access20 Nov 2020
Nature Communications

Volume: 11, P: 1-15
The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors

The E3-ubiquitin ligase APC/C and its cofactor Cdh1 have been shown to play important roles in axonal growth and synaptic plasticity. In this study, Eguren et al.show that elimination of Cdh1 in the developing nervous system results in defects in the neural progenitor compartment, hydrocephalus and reduced lifespan.

Manuel Eguren
Eva Porlan
Marcos Malumbres
Research04 Dec 2013
Nature Communications

Volume: 4, P: 1-16
Genomic stability and tumour suppression by the APC/C cofactor Cdh1

Irene García-Higuera
Eusebio Manchado
Marcos Malumbres
Research15 Jun 2008
Nature Cell Biology

Volume: 10, P: 802-811
APC/C-Cdh1 coordinates neurogenesis and cortical size during development

The E3 ubiquitin ligase APC/C plays a critical role in cell cycle progression. In this study, Delgado-Esteban et al. show that APC/C bound to the co-factor Cdh1 is necessary for neural progenitor cell maintenance and neuronal differentiation.

Maria Delgado-Esteban
Irene García-Higuera
Angeles Almeida
Research04 Dec 2013
Nature Communications

Volume: 4, P: 1-12
Efficient terminal erythroid differentiation requires the APC/C cofactor Cdh1 to limit replicative stress in erythroblasts

Myriam Cuadrado
Javier Garzón
Irene García-Higuera
ResearchOpen Access21 Jun 2022
Scientific Reports

Volume: 12, P: 1-13

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Regulation of cytokine signaling through direct interaction between cytokine receptors and the ATG16L1 WD40 domain

The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors

Genomic stability and tumour suppression by the APC/C cofactor Cdh1

APC/C-Cdh1 coordinates neurogenesis and cortical size during development

Efficient terminal erythroid differentiation requires the APC/C cofactor Cdh1 to limit replicative stress in erythroblasts

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