Two in vitro skin-like tissue models were used to recapitulate disease-relevant hallmarks of fibrosis. Anti-fibrogenic phenotypes were achieved upon inhibiting lysyl oxidase enzynes in these tissues. This study points to a pivotal role for lysyl oxidases in fibrosis and shows the value of these tissue-based platforms for discovering new therapeutics.
- Mengqi Huang
- Zhiyi Liu
- Jonathan Garlick
