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Showing 1–4 of 4 results
Advanced filters: Author: Irina Ankoudinova Clear advanced filters

  • This study extends the natural code by which transcription activation–like effector nucleases (TALENs) recognize DNA and uses the resulting expanded repertoire of repeat divariable residues (RVDs) to improve TALEN performance.

    • Jeffrey C Miller
    • Lei Zhang
    • Edward J Rebar
    Research
    Nature Methods
    Volume: 12, P: 465-471

  • TALEs (transcription activator-like effectors) are transcription factors from the plant pathogen Xanthomonas that can be readily engineered to bind new DNA sequences of interest. Miller et al. use a truncated TALE linked to a nuclease domain to edit and regulate endogenous genes in human cells.

    • Jeffrey C Miller
    • Siyuan Tan
    • Edward J Rebar
    Research
    Nature Biotechnology
    Volume: 29, P: 143-148