Here, the authors describe the mechanisms that normally limit function and survival of activated T cells in peripheral tissues and discuss how defects in these processes can facilitate the development of chronic inflammatory responses that underlie organ damage in rheumatic autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis.
- Florencia Rosetti
- Iris K. Madera-Salcedo
- José C. Crispín
