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Showing 1–6 of 6 results
Advanced filters: Author: Iris Uribesalgo Clear advanced filters

  • Nucleosomes can be modified by replacing the core histones with variants, the most diverse of which is macroH2A. The localization of macroH2A variants in human male pluripotent cells indicates that this variant functions in repression of key developmental genes and is essential for zebrafish embryogenesis.

    • Marcus Buschbeck
    • Iris Uribesalgo
    • Luciano Di Croce
    Research
    Nature Structural & Molecular Biology
    Volume: 16, P: 1074-1079

  • The MYC proto-oncogene modulates transcription through binding to E-boxes. Di Croce and colleagues find that PAK-2-mediated phosphorylation confers a tumour-suppressive function to MYC, in which MYC cooperates with differentiation signals to positively modulate the transcription of genes targeted by retinoic acid, independently of E-boxes.

    • Iris Uribesalgo
    • Marcus Buschbeck
    • Luciano Di Croce
    Research
    Nature Cell Biology
    Volume: 13, P: 1443-1449

  • The E3 ligase Cbl-b acts on TAM tyrosine kinase receptors and has a critical role in the regulation of natural killer (NK) cell rejection of metastatic tumours; a small molecule TAM kinase inhibitor is shown to enhance the anti-metastatic NK cell activity.

    • Magdalena Paolino
    • Axel Choidas
    • Josef M. Penninger
    Research
    Nature
    Volume: 507, P: 508-512