Nature Search

Microbiota-derived corisin accelerates kidney fibrosis by promoting cellular aging

Here, the authors identify the microbiota-derived corisin as a driver of diabetic kidney fibrosis via cellular aging and show that targeting corisin with a monoclonal antibody alleviates disease in mice, suggesting a potential therapeutic avenue.

Taro Yasuma
Hajime Fujimoto
Esteban C. Gabazza
ResearchOpen Access25 Aug 2025
Nature Communications

Volume: 16, P: 1-29
A pan-cancer dye for solid-tumour screening, resection and wound monitoring via short-wave and near-infrared fluorescence imaging

A commercial near-infrared dye that is sensitive to apoptosis and that provides high tumour-to-muscle and tumour-to-liver contrast ratios facilitates fluorescence-guided tumour screening, tumour resection and the assessment of wound healing.

Benedict Edward Mc Larney
Ali Yasin Sonay
Jan Grimm
Research09 Sept 2024
Nature Biomedical Engineering

Volume: 8, P: 1092-1108
Degradation of complex arabinoxylans by human colonic Bacteroidetes

Human gut bacteria can degrade arabinoxylans, polysaccharides found in dietary fiber. Here, Pereira et al. identify a bacterial gene cluster encoding esterases for degradation of complex arabinoxylans. The action of these enzymes results in accumulation of ferulic acid, a phenolic compound with antioxidative and immunomodulatory properties.

Gabriel V. Pereira
Ahmed M. Abdel-Hamid
Isaac Cann
ResearchOpen Access19 Jan 2021
Nature Communications

Volume: 12, P: 1-21
An expanded metabolic pathway for androgen production by commensal bacteria

Bacterial enzymes synthesize androgens that could promote cancer cell progression interfering with the efficacy of steroid-targeted prostate cancer therapies.

Taojun Wang
Saeed Ahmad
Jason M. Ridlon
Research21 Apr 2025
Nature Microbiology

Volume: 10, P: 1084-1098
Inhibition of lung microbiota-derived proapoptotic peptides ameliorates acute exacerbation of pulmonary fibrosis

Here, the authors show that treatment with a monoclonal neutralizing antibody against the lung microbiota-derived proapoptotic peptide corisin ameliorates acute exacerbation of pulmonary fibrosis and severity of endotoxin-induced acute lung injury in mice.

Corina N. D’Alessandro-Gabazza
Taro Yasuma
Esteban C. Gabazza
ResearchOpen Access23 Mar 2022
Nature Communications

Volume: 13, P: 1-23
Quantitative fluorescence labeling of aldehyde-tagged proteins for single-molecule imaging

The combination of a genetically encoded aldehyde tag and optimized labeling method allows high-efficiency, site-specific labeling of tagged proteins after purification or in cell extracts. The authors use the high labeling efficiency for single-molecule measurements of the dynamic interactions between two DNA polymerases and polymerase processivity factor bound to DNA.

Xinghua Shi
Yonil Jung
Taekjip Ha
Research01 Apr 2012
Nature Methods

Volume: 9, P: 499-503
A Staphylococcus pro-apoptotic peptide induces acute exacerbation of pulmonary fibrosis

Idiopathic pulmonary fibrosis is associated with increased abundance of Staphylococcus and Streptococcus in the lungs. Here, the authors identify a Staphylococcus nepalensis-derived peptide, named corisin, to induce apoptosis of lung epithelial cells and exacerbation of pulmonary fibrosis in mice.

Corina N. D’Alessandro-Gabazza
Tetsu Kobayashi
Esteban C. Gabazza
ResearchOpen Access24 Mar 2020
Nature Communications

Volume: 11, P: 1-17
PCNA is involved in the EndoQ-mediated DNA repair process in Thermococcales

Miyako Shiraishi
Sonoko Ishino
Yoshizumi Ishino
ResearchOpen Access06 May 2016
Scientific Reports

Volume: 6, P: 1-9
Let them eat fruit

Detailed biochemical, structural and growth studies reveal how Bacteroides thetaiotaomicron coordinates a complex enzymatic response to deconstruct pectins — complex dietary components that comprise a tremendous diversity of monosaccharide units and glycosidic linkage combinations.

Roderick I. Mackie
Isaac Cann
News & Views22 Jan 2018
Nature Microbiology

Volume: 3, P: 127-129
Diverse hydrogen production and consumption pathways influence methane production in ruminants

Chris Greening
Renae Geier
Roderick I. Mackie
ResearchOpen Access26 Jun 2019
The ISME Journal

Volume: 13, P: 2617-2632
The mesophilic archaeon Methanosarcina acetivorans counteracts uracil in DNA with multiple enzymes: EndoQ, ExoIII, and UDG

Miyako Shiraishi
Sonoko Ishino
Yoshizumi Ishino
ResearchOpen Access25 Oct 2018
Scientific Reports

Volume: 8, P: 1-14
Metabolic networks for nitrogen utilization in Prevotella ruminicola 23

Jong Nam Kim
Celia Méndez–García
Roderick I. Mackie
ResearchOpen Access10 Aug 2017
Scientific Reports

Volume: 7, P: 1-11
Bacteroides intestinalis DSM 17393, a member of the human colonic microbiome, upregulates multiple endoxylanases during growth on xylan

Kui Wang
Gabriel V. Pereira
Isaac Cann
ResearchOpen Access29 Sept 2016
Scientific Reports

Volume: 6, P: 1-11
Multiple cellobiohydrolases and cellobiose phosphorylases cooperate in the ruminal bacterium Ruminococcus albus 8 to degrade cellooligosaccharides

Saravanan Devendran
Ahmed M. Abdel-Hamid
Isaac Cann
ResearchOpen Access17 Oct 2016
Scientific Reports

Volume: 6, P: 1-15
Functional and modular analyses of diverse endoglucanases from Ruminococcus albus 8, a specialist plant cell wall degrading bacterium

Michael Iakiviak
Saravanan Devendran
Isaac Cann
ResearchOpen Access21 Jul 2016
Scientific Reports

Volume: 6, P: 1-13
Phylogenetic analysis of the fecal microbial community in herbivorous land and marine iguanas of the Galápagos Islands using 16S rRNA-based pyrosequencing

Pei-Ying Hong
Emily Wheeler
Roderick I Mackie
Research31 Mar 2011
The ISME Journal

Volume: 5, P: 1461-1470
Phylogenetic and gene-centric metagenomics of the canine intestinal microbiome reveals similarities with humans and mice

Kelly S Swanson
Scot E Dowd
George C Fahey Jr
Research21 Oct 2010
The ISME Journal

Volume: 5, P: 639-649

Search

Microbiota-derived corisin accelerates kidney fibrosis by promoting cellular aging

A pan-cancer dye for solid-tumour screening, resection and wound monitoring via short-wave and near-infrared fluorescence imaging

Degradation of complex arabinoxylans by human colonic Bacteroidetes

An expanded metabolic pathway for androgen production by commensal bacteria

Inhibition of lung microbiota-derived proapoptotic peptides ameliorates acute exacerbation of pulmonary fibrosis

Quantitative fluorescence labeling of aldehyde-tagged proteins for single-molecule imaging

A Staphylococcus pro-apoptotic peptide induces acute exacerbation of pulmonary fibrosis

PCNA is involved in the EndoQ-mediated DNA repair process in Thermococcales

Let them eat fruit

Diverse hydrogen production and consumption pathways influence methane production in ruminants

The mesophilic archaeon Methanosarcina acetivorans counteracts uracil in DNA with multiple enzymes: EndoQ, ExoIII, and UDG

Metabolic networks for nitrogen utilization in Prevotella ruminicola 23

Bacteroides intestinalis DSM 17393, a member of the human colonic microbiome, upregulates multiple endoxylanases during growth on xylan

Multiple cellobiohydrolases and cellobiose phosphorylases cooperate in the ruminal bacterium Ruminococcus albus 8 to degrade cellooligosaccharides

Functional and modular analyses of diverse endoglucanases from Ruminococcus albus 8, a specialist plant cell wall degrading bacterium

Phylogenetic analysis of the fecal microbial community in herbivorous land and marine iguanas of the Galápagos Islands using 16S rRNA-based pyrosequencing

Phylogenetic and gene-centric metagenomics of the canine intestinal microbiome reveals similarities with humans and mice

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