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A radiolabeled dendrimer non-invasively identifies and tracks innate immune cell activation in a mouse model of experimental autoimmune encephalomyelitis

Non-invasive strategies to detect and track activated myeloid cells will facilitate disease diagnosis and monitoring in patients affected by neuroinflammatory disorders. Here, the authors present 18F-FMD, a dendrimer-based PET tracer that detects and monitors activated myeloid cells at different stages (presymptomatic and symptomatic) of Experimental Autoimmune Encephalomyelitis (EAE) in mice and in response to disease-modifying therapies.

Renesmee C. Kuo
Mackenzie L. Carlson
Michelle L. James
ResearchOpen Access30 Jan 2026
Nature Communications

Volume: 17, P: 1-14
Speckle patterns permit direct observation of phase breaking

Moshe Kaveh
Michael Rosenbluh
Isaac Freund
Research01 Apr 1987
Nature

Volume: 326, P: 778-780
Jarid2 is induced by TCR signalling and controls iNKT cell maturation

The transcriptional regulator PLZF controls many of the key effector functions of invariant natural killer T (iNKT) cells but it is not clear how PLZF itself is regulated. Here, Pereira et al. demonstrate that a methlytransferase Jarid2 regulates PLZF expression and thus controls iNKT cell maturation.

Renata M. Pereira
Gustavo J. Martinez
Anjana Rao
Research08 Aug 2014
Nature Communications

Volume: 5, P: 1-14
CLEC16A in astrocytes promotes mitophagy and limits pathology in a multiple sclerosis mouse model

The mechanisms of pathological astrocyte responses during multiple sclerosis remain unclear. Kadowaki et al. found in MS mouse models that CLEC16A suppresses astrocyte pathogenic activities related to mitochondria by boosting mitophagy.

Atsushi Kadowaki
Michael A. Wheeler
Francisco J. Quintana
Research03 Mar 2025
Nature Neuroscience

Volume: 28, P: 470-486
Gut-licensed IFNγ⁺ NK cells drive LAMP1⁺TRAIL⁺ anti-inflammatory astrocytes

A subpopulation of astrocytes characterized by the expression of LAMP1 and TRAIL limits inflammation in the central nervous system through a mechanism involving the microbiota-modulated expression of IFNγ in meningeal natural killer cells.

Liliana M. Sanmarco
Michael A. Wheeler
Francisco J. Quintana
Research06 Jan 2021
Nature

Volume: 590, P: 473-479
Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314

Bacterial infection can cause pain but the underlying mechanism is unclear. This study shows pain induced in mice by methicillin-resistant Staphylococcus aureus infection is mediated by bacterial pore-forming toxins, and a sodium channel blocker QX-314 can alleviate infection-associated pain.

Kimbria J. Blake
Pankaj Baral
Isaac M. Chiu
ResearchOpen Access02 Jan 2018
Nature Communications

Volume: 9, P: 1-15
Pain and immunity: implications for host defence

This Review considers the link between pain and the immune system. Nociceptors are directly activated by immune mediators and microbial products and, in turn, release neuropeptides that shape immune responses. These neuroimmune pathways can contribute to protective immunity from infections but also lead to chronic pain.

Pankaj Baral
Swalpa Udit
Isaac M. Chiu
Reviews15 Mar 2019
Nature Reviews Immunology

Volume: 19, P: 433-447
Forebrain delta opioid receptors regulate the response of delta agonist in models of migraine and opioid-induced hyperalgesia

Isaac J. Dripps
Zachariah Bertels
Amynah A. Pradhan
ResearchOpen Access19 Oct 2020
Scientific Reports

Volume: 10, P: 1-12

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A radiolabeled dendrimer non-invasively identifies and tracks innate immune cell activation in a mouse model of experimental autoimmune encephalomyelitis

Speckle patterns permit direct observation of phase breaking

Jarid2 is induced by TCR signalling and controls iNKT cell maturation

CLEC16A in astrocytes promotes mitophagy and limits pathology in a multiple sclerosis mouse model

Gut-licensed IFNγ⁺ NK cells drive LAMP1⁺TRAIL⁺ anti-inflammatory astrocytes

Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314

Pain and immunity: implications for host defence

Forebrain delta opioid receptors regulate the response of delta agonist in models of migraine and opioid-induced hyperalgesia

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