Nature Search

Using sero-epidemiology to monitor disparities in vaccination and infection with SARS-CoV-2

Continued monitoring of SARS-CoV-2 at the population level is important for identifying at-risk groups. Here the authors analyse data from a serological surveillance platform in San Francisco and find considerable variation in infection and vaccination history by race/ethnicity and socioeconomic status.

Isobel Routledge
Saki Takahashi
Isabel Rodríguez-Barraquer
ResearchOpen Access04 May 2022
Nature Communications

Volume: 13, P: 1-7
Strength and durability of indirect protection against SARS-CoV-2 infection through vaccine and infection-acquired immunity

Vaccines and infection-acquired immunity reduce infection risk to close contacts through ‘indirect protection’. Here, the authors characterise the strength and durability of vaccine- and infection-acquired indirect protection against SARS-CoV-2 using surveillance data from residents of state prisons in California.

Sophia T. Tan
Isabel Rodríguez-Barraquer
Nathan C. Lo
ResearchOpen Access29 Jan 2025
Nature Communications

Volume: 16, P: 1-10
Household immunity and individual risk of infection with dengue virus in a prospective, longitudinal cohort study

Herd immunity to dengue acts at the household level according to a longitudinal, multigenerational cohort study.

Marco Hamins-Puértolas
Darunee Buddhari
Kathryn B. Anderson
Research18 Dec 2023
Nature Microbiology

Volume: 9, P: 274-283
Infectiousness of SARS-CoV-2 breakthrough infections and reinfections during the Omicron wave

Analysis of data from California prisons shows that both COVID-19 vaccination and prior SARS-CoV-2 infection reduces the risk of virus transmission to close contacts.

Sophia T. Tan
Ada T. Kwan
Nathan C. Lo
Research02 Jan 2023
Nature Medicine

Volume: 29, P: 358-365
A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity

Antibody mediated immunity to SARS-CoV-2 will affect future transmission and disease severity. This systematic review on antibody response to coronaviruses, including SARS-CoV-2, SARS-CoV, MERS-CoV and endemic coronaviruses provides insights into kinetics, correlates of protection, and association with disease severity.

Angkana T. Huang
Bernardo Garcia-Carreras
Derek A. T. Cummings
ResearchOpen Access17 Sept 2020
Nature Communications

Volume: 11, P: 1-16
Evaluation of the extended efficacy of the Dengvaxia vaccine against symptomatic and subclinical dengue infection

Multiyear analysis of antibody responses in recipients of the dengue vaccine Dengvaxia in the Philippines supports their utility as a predictor of protection against disease, and reveals that Dengvaxia efficacy declines 3 years after complete vaccination.

Henrik Salje
Maria Theresa Alera
Alan L. Rothman
Research24 Jun 2021
Nature Medicine

Volume: 27, P: 1395-1400
The impact of stopping and starting indoor residual spraying on malaria burden in Uganda

Indoor residual spraying (IRS) of insecticide is one of the primary malaria vector control initiatives, but implementation is limited. Here, the authors show that discontinuation of IRS in Uganda was associated with increased malaria incidence, and introduction of IRS was associated with decreased incidence.

Jane F. Namuganga
Adrienne Epstein
Isabel Rodriguez-Barraquer
ResearchOpen Access11 May 2021
Nature Communications

Volume: 12, P: 1-9
Trade-offs between individual and ensemble forecasts of an emerging infectious disease

Newly emerged pathogens are inherently difficult to forecast, due to many unknowns about their biology early in an epidemic. Here, the authors assess forecasts of a suite of models during the Zika epidemic in Colombia, finding that the models that performed best changed over the course of the epidemic.

Rachel J. Oidtman
Elisa Omodei
T. Alex Perkins
ResearchOpen Access10 Sept 2021
Nature Communications

Volume: 12, P: 1-11
Citywide serosurveillance of the initial SARS-CoV-2 outbreak in San Francisco using electronic health records

Population-based surveys are the gold standard for estimating seroprevalence but are expensive and often only capture a small geographic area or window of time. This study describes a new platform, SCALE-IT, for serosurveillance based on algorithmic sampling of electronic health records, and uses it to estimate the seroprevalence of SARS-CoV-2 in San Francisco.

Isobel Routledge
Adrienne Epstein
Isabel Rodriguez-Barraquer
ResearchOpen Access11 Jun 2021
Nature Communications

Volume: 12, P: 1-9
Pareto rules for malaria super-spreaders and super-spreading

Investigating malaria transmission at three sites in Uganda, the authors identify super-spreaders and show that super-spreading is more prominent at low-intensity transmission, and that seasonality and environmental stochasticity have a greater influence on super-spreading.

Laura Cooper
Su Yun Kang
David L. Smith
ResearchOpen Access02 Sept 2019
Nature Communications

Volume: 10, P: 1-9
Impacts of Zika emergence in Latin America on endemic dengue transmission

Dengue and Zika virus are related flaviviruses, and introduction of Zika in the Americas may have impacted dengue epidemiology. Here, Borchering et al. show that dengue incidence was unusually low in 2017 in Brazil and Colombia, and simulations incorporating immune-mediated interactions predict reductions in dengue following Zika outbreaks with subsequent rebounds.

Rebecca K. Borchering
Angkana T. Huang
Derek A. T. Cummings
ResearchOpen Access16 Dec 2019
Nature Communications

Volume: 10, P: 1-9
Reconstruction of antibody dynamics and infection histories to evaluate dengue risk

Analyses of antibody dynamics and subclinical infections show that across the population, variability in the infection strength of dengue viruses results in large-scale temporal changes in infection and disease risk that correlate poorly with age.

Henrik Salje
Derek A. T. Cummings
Simon Cauchemez
Research23 May 2018
Nature

Volume: 557, P: 719-723
Risk factor targeting for vaccine prioritization during the COVID-19 pandemic

Lloyd A. C. Chapman
Poojan Shukla
Nathan C. Lo
ResearchOpen Access23 Feb 2022
Scientific Reports

Volume: 12, P: 1-12
Spatiotemporal incidence of Zika and associated environmental drivers for the 2015-2016 epidemic in Colombia

Amir S. Siraj
Isabel Rodriguez-Barraquer
T. Alex Perkins
ResearchOpen Access24 Apr 2018
Scientific Data

Volume: 5, P: 1-11

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