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Showing 1–10 of 10 results
Advanced filters: Author: Isabelle Brun Heath Clear advanced filters

  • Multi-layered epigenetic regulation in higher eukaryotes makes it challenging to disentangle the individual effects of modifications on chromatin structure and function. Here, the authors expressed mammalian DNA methyltransferases in yeast, which have no DNA methylation, to show that methylation has intrinsic effects on chromatin structure.

    • Diana Buitrago
    • Mireia Labrador
    • Modesto Orozco
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Accurate analysis of mitochondrial DNA is important for mitochondrial disease clinical research and diagnostics. Here, authors present a method using Cas9 cleavage, nanopore sequencing and a custom pipeline to identify pathogenic variants, deletions and accurately quantify heteroplasmy to below 1%.

    • Ieva Keraite
    • Philipp Becker
    • Ivo Glynne Gut
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • Histone post-translational modifications control several fundamental processes on DNA. Here, the authors describe a conserved phosphorylation of histone H3 on the globular core and show that it loosens the nucleosome and regulates DNA repair.

    • Nikolaos Parisis
    • Pablo D. Dans
    • Daniel Fisher
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20

  • Transcription factors are rich in intrinsic disorder and therefore hard to drug. The authors improve an experimental drug for castration-resistant prostate cancer by learning how the activation domain of the androgen receptor activates transcription.

    • Shaon Basu
    • Paula Martínez-Cristóbal
    • Xavier Salvatella
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 1958-1969

  • Hsp chaperones stabilize the inactive conformation of androgen receptor (AR) and are released upon hormone-induced AR activation. Here, the authors locate the Hsp binding region on AR, and show that Hsp70 reduces AR aggregation and promotes AR degradation in cellular and mouse models of a neuromuscular disorder.

    • Bahareh Eftekharzadeh
    • Varuna C. Banduseela
    • Xavier Salvatella
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Small molecules bioactivity descriptors are enriched representations of compounds, reaching beyond chemical structures and capturing their known biological properties. Here the authors present a collection of deep neural networks able to infer bioactivity signatures for any compound of interest, even when little or no experimental information is available for them.

    • Martino Bertoni
    • Miquel Duran-Frigola
    • Patrick Aloy
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • The p38α protein kinase is an attractive druggable target for many human diseases. Here, the authors show how the structural plasticity of p38α can be leveraged to selectively inhibit a subset of the functions regulated by this kinase and aid in the development of therapeutic compounds.

    • Lorena González
    • Lucía Díaz
    • Angel R. Nebreda
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • José Martin-Subero and colleagues report whole-genome bisulfite sequencing and methylome analysis of two CLLs and three B-cell subpopulations using high-density microarrays on 139 CLLs. They identify widespread hypomethylation in the gene body that is largely associated with intragenic enhancer elements.

    • Marta Kulis
    • Simon Heath
    • José I Martín-Subero
    Research
    Nature Genetics
    Volume: 44, P: 1236-1242