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Advanced filters: Author: Isabelle Chion-Sotinel Clear advanced filters

  • Host versus graft reaction is a major impediment to CAR-T cell immune therapy in allogeneic settings. Authors show here that CAR-T cells, engineered to be deficient in MHC I expression but to express the NK inhibitor HLA-E, are resistant to destruction by both T and NK cells of the host.

    • Sumin Jo
    • Shipra Das
    • Julien Valton
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16