Nature Search

Cellular diversity in the colon: another brick in the wall

Single-cell RNA profiling of colonic epithelial crypts from healthy volunteers and patients with ulcerative colitis adds pH-regulating colonocytes and goblet cells expressing a major determinant of barrier maintenance to the current arsenal of uncovered colonic epithelial cell types.

Isabelle Cleynen
Debby Laukens
News & Views03 Jun 2019
Nature Reviews Gastroenterology & Hepatology

Volume: 16, P: 391-392
Paradoxical inflammation induced by anti-TNF agents in patients with IBD

Anti-TNF antibodies have acquired a prominent place in the management of IBD. However, with increasing use of these agents, paradoxical adverse effects involving the skin, joints and lungs have been reported. The authors review the paradoxical inflammation induced by anti-TNF agents in patients with IBD, provide hypotheses for the occurrence of this paradoxical inflammation and give practical advice on how to manage these patients.

Isabelle Cleynen
Séverine Vermeire
Reviews03 Jul 2012
Nature Reviews Gastroenterology & Hepatology

Volume: 9, P: 496-503
Large-scale sequencing identifies multiple genes and rare variants associated with Crohn’s disease susceptibility

Large-scale sequence-based analyses identify novel risk variants and susceptibility genes for Crohn’s disease, and implicate mesenchymal cell-mediated intestinal homeostasis in disease etiology.

Aleksejs Sazonovs
Christine R. Stevens
Mark J. Daly
Research29 Aug 2022
Nature Genetics

Volume: 54, P: 1275-1283
Fine-mapping inflammatory bowel disease loci to single-variant resolution

Results of fine-mapping 94 inflammatory bowel disease loci using high-density genotyping in 67,852 individuals and several new fine-mapping methods.

Hailiang Huang
Ming Fang
Jeffrey C. Barrett
Research28 Jun 2017
Nature

Volume: 547, P: 173-178
Quantitative microbiome profiling disentangles inflammation- and bile duct obstruction-associated microbiota alterations across PSC/IBD diagnoses

Here, the authors apply quantitative microbiome profiling to a metagenomics data set comprising patients with primary sclerosing cholangitis and/or inflammatory bowel disease and identify microbial taxa associated with inflammation or specific disease indicators, which were validated in an independent inflammatory bowel disease cohort.

Sara Vieira-Silva
João Sabino
Jeroen Raes
Research17 Jun 2019
Nature Microbiology

Volume: 4, P: 1826-1831
Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion

Isabelle Cleynen
Worrawat Engchuan
Anne S. Bassett
Research03 Feb 2020
Molecular Psychiatry

Volume: 26, P: 4496-4510
Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

A meta-analysis of previous genome-wide association studies of Crohn’s disease and ulcerative colitis, the two most common forms of inflammatory bowel disease, with a combined total of more than 75,000 cases and controls, finds that most loci contribute to both phenotypes and other immune-mediated disorders.

Luke Jostins
Stephan Ripke
Judy H Cho
Research31 Oct 2012
Nature

Volume: 491, P: 119-124
Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease

Michel Georges and colleagues perform high-throughput resequencing of 63 positional candidate genes identified through genome-wide association studies to search for rare coding variants influencing risk of Crohn's disease. They identify low-frequency coding variants in IL23R that confer protection against inflammatory bowel disease but conclude that rare coding variants in these positional candidates do not make a large contribution to Crohn's disease risk.

Yukihide Momozawa
Myriam Mni
Michel Georges
Research12 Dec 2010
Nature Genetics

Volume: 43, P: 43-47
Genome-wide association study of Alzheimer’s disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset

Shengjun Hong
Dmitry Prokopenko
Lars Bertram
ResearchOpen Access22 Nov 2020
Translational Psychiatry

Volume: 10, P: 1-12
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis

Tom Karlsen and colleagues report an association study for primary sclerosing cholangitis (PSC), a severe liver disease, using the Immunochip array. They identify nine loci newly associated with PSC and examine pleiotropy with other autoimmune disorders.

Jimmy Z Liu
Johannes Roksund Hov
Tom H Karlsen
Research21 Apr 2013
Nature Genetics

Volume: 45, P: 670-675
IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

Most of the more than 200 known genetic risk loci for inflammatory bowel disease (IBD) reside in regulatory regions. Here, the authors provide eQTL datasets for six circulating immune cell types and ileal, colonic and rectal biopsies to map regulatory modules and identify potential causative genes for IBD.

Yukihide Momozawa
Julia Dmitrieva
Michel Georges
ResearchOpen Access21 Jun 2018
Nature Communications

Volume: 9, P: 1-18
High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

John Rioux, Andre Franke, Tom Karlsen and colleagues perform a fine-mapping study of the HLA region in Crohn's disease and ulcerative colitis. They identify a primary role for HLA-DRB1*01:03 in both diseases and find evidence of heterozygous advantage in protection against ulcerative colitis.

Philippe Goyette
Gabrielle Boucher
John D Rioux
Research05 Jan 2015
Nature Genetics

Volume: 47, P: 172-179
Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data

Alberto Romagnoni
Simon Jégou
Pamela Whittaker
ResearchOpen Access17 Jul 2019
Scientific Reports

Volume: 9, P: 1-18

Search

Cellular diversity in the colon: another brick in the wall

Paradoxical inflammation induced by anti-TNF agents in patients with IBD

Large-scale sequencing identifies multiple genes and rare variants associated with Crohn’s disease susceptibility

Fine-mapping inflammatory bowel disease loci to single-variant resolution

Quantitative microbiome profiling disentangles inflammation- and bile duct obstruction-associated microbiota alterations across PSC/IBD diagnoses

Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease

Genome-wide association study of Alzheimer’s disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis

IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data

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