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Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics

Steve Brown and colleagues report an analysis of 20 phenotyping tests, including 413 data parameters, across 449 mutant mouse alleles. They identify widespread pleiotropy and assign putative functions to genes that lacked previous phenotypic annotation.

Martin Hrabě de Angelis
George Nicholson
Steve D M Brown
Research27 Jul 2015
Nature Genetics

Volume: 47, P: 969-978
Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma

Senescence can have beneficial and detrimental impact on cancer progression depending on the cellular context. Here the authors show that NRF2 regulates the senescence phenotype in malignant cells which consequently contribute to glioblastoma progression.

Rana Salam
Alexa Saliou
Isabelle Le Roux
ResearchOpen Access27 Jan 2023
Nature Communications

Volume: 14, P: 1-21
Airway environment drives the selection of quorum sensing mutants and promote Staphylococcus aureus chronic lifestyle

This study by Ding et al reveals that the quorum-sensing dysfunction typically encountered in lung-adapted Staphylococcus aureus isolates could be selected by an enhanced ability to consume sialic acid released from airway mucins by the microbiota.

Xiongqi Ding
Catherine Robbe-Masselot
Anne Jamet
ResearchOpen Access08 Dec 2023
Nature Communications

Volume: 14, P: 1-13
Different Acute-Phase Response in Newborns and Infants Undergoing Surgery

Edwin Bölke
Peter M Jehle
Klaus Orth
Research01 Mar 2002
Pediatric Research

Volume: 51, P: 333-338
Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses

The Lpp lipoproteins of staphylococci trigger a TLR2-dependent immune response. Here, the authors show that commensal species (S. aureus, S. epidermidis) induce a less-intense TLR2 response than non-commensal species (S. carnosus) due to differential modification of the Lpp lipid moieties.

Minh-Thu Nguyen
Julia Uebele
Friedrich Götz
ResearchOpen Access21 Dec 2017
Nature Communications

Volume: 8, P: 1-12
Chemoorganoautotrophic lifestyle of the anaerobic enrichment culture N47 growing on naphthalene

A “chemoorganoautotrophic” metabolism using both the citric acid cycle and Wood-Ljungdahl pathway in an anaerobic naphthalene degrader was identified by analysis of ¹³C-label incorporation into amino acids and fatty acids, together with enzyme assays.

Isabelle Heker
Christian Seitz
Rainer U. Meckenstock
ResearchOpen Access04 Jun 2025
Communications Biology

Volume: 8, P: 1-13

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Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics

Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma

Airway environment drives the selection of quorum sensing mutants and promote Staphylococcus aureus chronic lifestyle

Different Acute-Phase Response in Newborns and Infants Undergoing Surgery

Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses

Chemoorganoautotrophic lifestyle of the anaerobic enrichment culture N47 growing on naphthalene

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Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics

Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma

Airway environment drives the selection of quorum sensing mutants and promote Staphylococcus aureus chronic lifestyle

Different Acute-Phase Response in Newborns and Infants Undergoing Surgery

Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses

Chemoorganoautotrophic lifestyle of the anaerobic enrichment culture N47 growing on naphthalene

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Quick links