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Showing 1–3 of 3 results

Advanced filters: Author: Isabelle McCort-Tranchepain Clear advanced filters

Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement

Plasmacytoid dendritic cells produce type I interferons in response to viral sensing. Here the authors show that amines inhibit these plasmacytoid dendritic cell responses through CXCR4 engagement.

Nikaïa Smith
Nicolas Pietrancosta
Jean-Philippe Herbeuval
ResearchOpen Access09 Feb 2017
Nature Communications

Volume: 8, P: 1-13
MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes

Jungnickel, Guelle et al. use metabolomics, electrophysiology and cryo-EM approaches to show that MFSD1 is a lysosomal dipeptide uniporter, which provides an additional route to recycle lysosomal proteolysis products to lysosomal amino acid exporters.

Katharina Esther Julia Jungnickel
Océane Guelle
Markus Damme
ResearchOpen Access05 Jun 2024
Nature Cell Biology

Volume: 26, P: 1047-1061
Conformational pathway provides unique sensitivity to a synaptic mGluR

Metabotropic glutamate receptors (mGluRs) are dimeric G-protein–coupled receptors that operate at neural synapses. Here authors use FRET assays in live cells to monitor mGluR2/7’s activation and reveal how heterodimerization can alter the glutamate response of an mGluR.

Chris H. Habrian
Joshua Levitz
Ehud Y. Isacoff
ResearchOpen Access05 Dec 2019
Nature Communications

Volume: 10, P: 1-13