Epithelial cells express two isoforms of cytoplasmic actin, γ- and β-actin, and whether isoform-specific functions exist is debated. Here, the authors report a feedback circuitry whereby γ-actin regulates the expression of β-actin and nonmuscle myosin-2A, and modulate apical membrane cortex mechanics and cytoplasmic tight junction protein dynamics.
- Marine Maupérin
- Yuze Sun
- Sandra Citi
