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Generation of T-cell-receptor-negative CD8αβ-positive CAR T cells from T-cell-derived induced pluripotent stem cells

Potent allogeneic CD8αβ⁺ CAR T cells devoid of alloreactive potential can be generated from human T-cell-derived induced pluripotent stem cells via the timed and calibrated expression of a CAR that substitutes for the T-cell receptor.

Sjoukje J. C. van der Stegen
Pieter L. Lindenbergh
Michel Sadelain
Research08 Aug 2022
Nature Biomedical Engineering

Volume: 6, P: 1284-1297
Molecular characterization of the missing electron pathways for butanol synthesis in Clostridium acetobutylicum

Ferredoxin-NAD(P) + oxidoreductases are important enzymes for redox balancing in n-butanol production by Clostridium acetobutylicum, but the encoding genes remain unknown. Here, the authors identify the long sought-after genes and increase n-butanol production by optimizing the levels of the two enzymes.

Céline Foulquier
Antoine Rivière
Isabelle Meynial-Salles
ResearchOpen Access10 Aug 2022
Nature Communications

Volume: 13, P: 1-11
Epidemiology of acute gastroenteritis in France from November 2019–August 2021, in light of reported adherence to COVID-19 barrier measures

Athinna Nisavanh
Imene Horrigue
Gabrielle Jones
ResearchOpen Access19 Oct 2022
Scientific Reports

Volume: 12, P: 1-10
A genetic strategy to treat sickle cell anemia by coregulating globin transgene expression and RNA interference

Selda Samakoglu
Leszek Lisowski
Michel Sadelain
Research25 Dec 2005
Nature Biotechnology

Volume: 24, P: 89-94
HLA-independent T cell receptors for targeting tumors with low antigen density

HLA-independent T cell receptors, in which the heavy and light chains of a chimeric antigen receptor are incorporated into the endogenous T cell receptor locus, are more effective than CD28-based chimeric antigen receptors at targeting tumors with low antigen expression.

Jorge Mansilla-Soto
Justin Eyquem
Michel Sadelain
Research13 Jan 2022
Nature Medicine

Volume: 28, P: 345-352
Lentiviral globin gene therapy with reduced-intensity conditioning in adults with β-thalassemia: a phase 1 trial

A gene therapy phase 1 trial in patients with β-thalassemia shows transplantation of autologous CD34⁺ cells transduced with a lentiviral globin vector after reduced-intensity conditioning achieves long-term engraftment, albeit not transfusion independence, with benign clonal expansions, warranting cautious monitoring of patients.

Farid Boulad
Aurelio Maggio
Michel Sadelain
Research03 Jan 2022
Nature Medicine

Volume: 28, P: 63-70
Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRζ /CD28 receptor

John Maher
Renier J. Brentjens
Michel Sadelain
Research01 Jan 2002
Nature Biotechnology

Volume: 20, P: 70-75
Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15

Renier J. Brentjens
Jean-Baptiste Latouche
Michel Sadelain
Research10 Feb 2003
Nature Medicine

Volume: 9, P: 279-286
Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice

Circadian disruption is implicated in the development of different human cancers. Here the authors show that chronic circadian disruption, through continuous jet lag, only moderately affects primary tumour growth but promotes cancer-cell dissemination and metastasis in a mouse model of spontaneous mammary tumorigenesis.

Eva Hadadi
William Taylor
Hervé Acloque
ResearchOpen Access24 Jun 2020
Nature Communications

Volume: 11, P: 1-17
CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape

Chimeric antigen receptors (CARs) promote antigen loss in tumour cells by trogocytosis, which results in T cell fratricide killing and exhaustion but can be counteracted by cooperative killing and combinatorial targeting.

Mohamad Hamieh
Anton Dobrin
Michel Sadelain
Research27 Mar 2019
Nature

Volume: 568, P: 112-116
Targeting tumours with genetically enhanced T lymphocytes

Michel Sadelain
Isabelle Rivière
Renier Brentjens
Reviews01 Jan 2003
Nature Reviews Cancer

Volume: 3, P: 35-45
Defining the risk of first intravenous immunoglobulin unresponsiveness in non-Asian patients with Kawasaki disease

Maryam Piram
Martha Darce Bello
Isabelle Koné-Paut
ResearchOpen Access20 Feb 2020
Scientific Reports

Volume: 10, P: 1-10
The ABCs of artificial antigen presentation

Jiyun V Kim
Jean-Baptiste Latouche
Michel Sadelain
Reviews31 Mar 2004
Nature Biotechnology

Volume: 22, P: 403-410
Therapeutic T cell engineering

The use of genetically engineered T cells in the treatment of cancer is reviewed, with particular focus on anti-CD19 chimaeric antigen receptor therapy, providing a summary of past progress and current status, and potential future directions.

Michel Sadelain
Isabelle Rivière
Stanley Riddell
Reviews25 May 2017
Nature

Volume: 545, P: 423-431
Scrutiny of Mycobacterium tuberculosis 19 kDa antigen proteoforms provides new insights in the lipoglycoprotein biogenesis paradigm

Julien Parra
Julien Marcoux
Michel Rivière
ResearchOpen Access08 Mar 2017
Scientific Reports

Volume: 7, P: 1-12
Long-term improvement of breast cancer survivors’ quality of life by a 2-week group physical and educational intervention: 5-year update of the ‘PACThe’ trial

Fabrice Kwiatkowski
Marie-Ange Mouret-Reynier
Yves-Jean Bignon
ResearchOpen Access20 Apr 2017
British Journal of Cancer

Volume: 116, P: 1389-1393

Search

Generation of T-cell-receptor-negative CD8αβ-positive CAR T cells from T-cell-derived induced pluripotent stem cells

Molecular characterization of the missing electron pathways for butanol synthesis in Clostridium acetobutylicum

Epidemiology of acute gastroenteritis in France from November 2019–August 2021, in light of reported adherence to COVID-19 barrier measures

A genetic strategy to treat sickle cell anemia by coregulating globin transgene expression and RNA interference

HLA-independent T cell receptors for targeting tumors with low antigen density

Lentiviral globin gene therapy with reduced-intensity conditioning in adults with β-thalassemia: a phase 1 trial

Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRζ /CD28 receptor

Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15

Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice

CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape

Targeting tumours with genetically enhanced T lymphocytes

Defining the risk of first intravenous immunoglobulin unresponsiveness in non-Asian patients with Kawasaki disease

The ABCs of artificial antigen presentation

Therapeutic T cell engineering

Scrutiny of Mycobacterium tuberculosis 19 kDa antigen proteoforms provides new insights in the lipoglycoprotein biogenesis paradigm

Long-term improvement of breast cancer survivors’ quality of life by a 2-week group physical and educational intervention: 5-year update of the ‘PACThe’ trial

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