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Showing 1–2 of 2 results
Advanced filters: Author: Isabelle Schiffer Clear advanced filters

  • Immune checkpoint blockade could improve the complete cytoreduction rate with standard-of-care neoadjuvant chemotherapy (NACT) in patients with ovarian cancer. Here the authors report the results of a randomized phase II trial of NACT alone or in combination with pembrolizumab (anti-PD1) in patients with advanced high-grade serous carcinoma.

    • Isabelle L. Ray-Coquard
    • Aude-Marie Savoye
    • Olivier Tredan
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • Tharyan et al. identify NFYB-1 as a regulator of mitochondrial function that represses lysosomal prosaposin. The NFYB-1–prosaposin signalling axis coordinates lysosomal-to-mitochondria signalling via cardiolipin to enhance cellular mitochondrial function and longevity in C. elegans.

    • Rebecca George Tharyan
    • Andrea Annibal
    • Adam Antebi
    Research
    Nature Metabolism
    Volume: 2, P: 387-396