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Showing 1–7 of 7 results
Advanced filters: Author: Isaia Barbieri Clear advanced filters

  • A strategy for protecting redox-active ortho-quinones, which show promise as anticancer agents but suffer from redox-cycling behaviour and systemic toxicity, has been developed. The ortho-quinones are derivatized to redox-inactive para-aminobenzyl ketols. Upon amine deprotection, an acid-promoted, self-immolative C–C bond-cleaving 1,6-elimination releases the redox-active hydroquinone. The strategy also enables conjugation to a carrier for targeted delivery of ortho-quinone species.

    • Lavinia Dunsmore
    • Claudio D. Navo
    • Gonçalo J. L. Bernardes
    ResearchOpen Access
    Nature Chemistry
    Volume: 14, P: 754-765

  • Nanopore direct RNA Sequencing data contain information about the presence of RNA modifications, but their detection poses substantial challenges. Here the authors introduce Nanocompore, a new methodology for modification detection from Nanopore data.

    • Adrien Leger
    • Paulo P. Amaral
    • Tony Kouzarides
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Here the authors show thatMETTL9 enzyme sustains neural development in vertebrates by maintaining the secretory pathway, mainly independently of METTL9 catalytic activity. METTL9 loss in cells leads to Golgi fragmentation.

    • Azzurra Codino
    • Luca Spagnoletti
    • Luca Pandolfini
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-29

  • SRPK1, a kinase involved in splicing regulation, is a potential therapeutic target for AML patients. Here, the authors show that SRPK1 inhibition changes isoform levels of key epigenetic regulators, including BRD4, and it has anti-tumor effects specifically against MLL-rearranged AML cells.

    • Konstantinos Tzelepis
    • Etienne De Braekeleer
    • George S. Vassiliou
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • After synthesis, all RNA molecules are subject to covalent modifications. This Review presents the evidence that RNA modification pathways are misregulated in cancer and suggests that they may be ideal targets for cancer therapy.

    • Isaia Barbieri
    • Tony Kouzarides
    Reviews
    Nature Reviews Cancer
    Volume: 20, P: 303-322