A reliable supply of antigen-specific human antibodies could be useful for treating many diseases. Kuroiwa et al. use multiple rounds of genetic modification and cloning to generate a calf carrying human immunoglobulin genes and lacking bovine immunoglobulin genes, and show that the hyperimmunized animal produces >2 g/l of antigen-specific human polyclonal antibodies.
- Yoshimi Kuroiwa
- Poothappillai Kasinathan
- James M Robl
