Nature Search

Structure-guided phage display discovery of antibodies for (S)Tn-glycans in protein context

Structural studies of certain Tn and STn antigen-targeting antibodies reveal that their V_H and V_L domains recognize the glycan antigen and the adjacent peptide region, respectively, enabling a V_H domain-focused and V_L domain-varying phage display library to generate antibodies targeting diverse glycopeptide epitopes.

Ramon Hurtado-Guerrero
Spyridon Gatos
Ola Blixt
Research31 Jul 2025
Nature Chemical Biology

P: 1-12
Molecular basis for bacterial N-glycosylation by a soluble HMW1C-like N-glycosyltransferase

NGTs glycosylate asparagine residues in proteins, crucial for bacterial adhesion and pathogenicity. Here, the authors provide insights via crystallography and simulations, showing acceptor asparagine uses imidic form for catalysis and UDP-glucose phosphate group acts as general base.

Beatriz Piniello
Javier Macías-León
Ramon Hurtado-Guerrero
ResearchOpen Access18 Sept 2023
Nature Communications

Volume: 14, P: 1-15
Author Correction: Molecular basis for bacterial N-glycosylation by a soluble HMW1C-like N-glycosyltransferase

Beatriz Piniello
Javier Macías-León
Ramon Hurtado-Guerrero
Amendments and CorrectionsOpen Access13 Feb 2024
Nature Communications

Volume: 15, P: 1
Control of a hippocampal recurrent excitatory circuit by cannabinoid receptor-interacting protein Gap43

Cannabis impacts our brain by engaging the CB₁ receptor. Here, the authors identify a protein called GAP43 that interacts with CB₁ and blocks its synaptic functions. This finding provides a conceptual view to understand how CB₁ acts in the brain.

Irene B. Maroto
Carlos Costas-Insua
Manuel Guzmán
ResearchOpen Access21 Apr 2023
Nature Communications

Volume: 14, P: 1-16
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Interim safety and immunogenicity results from an NDV-based COVID-19 vaccine phase I trial in Mexico

Samuel Ponce-de-León
Martha Torres
Bernardo Lozano-Dubernard
ResearchOpen Access10 May 2023
npj Vaccines

Volume: 8, P: 1-14
Mortality and biochemical recurrence after surgery, brachytherapy, or external radiotherapy for localized prostate cancer: a 10-year follow-up cohort study

José Francisco Suárez
Víctor Zamora
María José Ortiz
ResearchOpen Access22 Jul 2022
Scientific Reports

Volume: 12, P: 1-9
Whole-exome sequencing reveals acquisition of mutations leading to the onset of donor cell leukemia after hematopoietic transplantation: a model of leukemogenesis

Julia Suárez-González
Carolina Martínez-Laperche
Ismael Buño
Research05 Feb 2018
Leukemia

Volume: 32, P: 1822-1826
Metabolite and lipoprotein profiles reveal sex-related oxidative stress imbalance in de novo drug-naive Parkinson’s disease patients

Gaia Meoni
Leonardo Tenori
Claudio Luchinat
ResearchOpen Access08 Feb 2022
npj Parkinson's Disease

Volume: 8, P: 1-10
Heterogeneity of prodromal Parkinson symptoms in siblings of Parkinson disease patients

Luca Baldelli
Sebastian Schade
Federica Provini
ResearchOpen Access07 Sept 2021
npj Parkinson's Disease

Volume: 7, P: 1-10
Lauren subtypes of advanced gastric cancer influence survival and response to chemotherapy: real-world data from the AGAMENON National Cancer Registry

Paula Jiménez Fonseca
Alberto Carmona-Bayonas
J Gallego
ResearchOpen Access01 Aug 2017
British Journal of Cancer

Volume: 117, P: 775-782

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