Potassium-chloride co-transporter 2 (KCC2) activity is known to be attenuated by neural injury. Hershfinkel et al. show that KCC2 activity is inhibited by intracellular free zinc, a component of neuronal injury signaling pathways. Oxygen-glucose deprivation results in attenuation of KCC2 activity that is reversible by intracellular zinc chelation.
- Michal Hershfinkel
- Karl Kandler
- Elias Aizenman