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Showing 1–5 of 5 results
Advanced filters: Author: Issam Makhoul Clear advanced filters

  • Aromatase inhibitors are the most effective agents for preventing breast cancer; however, their use is associated with bone loss and an increased risk of fractures. Sestak and colleagues show that administration of an oral bisphosphonate prevents aromatase-inhibitor-induced bone loss in postmenopausal women with osteopenia or osteoporosis who are at high risk of breast cancer.

    • Larry J. Suva
    • Issam Makhoul
    News & Views
    Nature Reviews Endocrinology
    Volume: 11, P: 138-139

  • Advances in the development of bone-modifying agents have led to the approval of new drugs for the prevention and treatment of skeletal-related events in patients with bone metastases from breast cancer. In light of these advances, the American Society of Clinical Oncology has published a guideline update.

    • Larry J. Suva
    • Brooke E. Brander
    • Issam Makhoul
    News & Views
    Nature Reviews Endocrinology
    Volume: 7, P: 380-381

  • Bild and colleagues identify convergent clonal evolution mechanisms through single-cell genomic analyses, explaining therapy resistance in patients with early-stage breast cancer treated with endocrine and CDK4/6 therapy in the FELINE trial.

    • Jason I. Griffiths
    • Jinfeng Chen
    • Andrea H. Bild
    Research
    Nature Cancer
    Volume: 2, P: 658-671

  • The skeleton has a central role in the development and regulation of bone metastasis. Here, Larry Suva and colleagues review the skeletal consequences of bone metastasis from an orthopaedic perspective. The authors discuss the effects of existing cancer treatments on bone and the bone marrow microenvironment, as well as the mechanisms mediating these effects and the current utility of modern orthopaedic interventions.

    • Issam Makhoul
    • Corey O. Montgomery
    • Larry J. Suva
    Reviews
    Nature Reviews Endocrinology
    Volume: 12, P: 29-42