EXO1 has a structural role to promote the MLH1-MLH3 nuclease complex to process meiotic recombination intermediates into crossovers. Here, the authors demonstrate that EXO1 function depends on conserved interactions with the MSH4 subunit of MSH4-MSH5, the MLH1 subunit of MLH1-MLH3, and DNA.
- Megha Roy
- Aurore Sanchez
- Petr Cejka