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Showing 1–2 of 2 results
Advanced filters: Author: Issra Osman Clear advanced filters

  • Different processes are in place to facilitate RNA-Polymerase 2 (Pol2) binding to chromatin. Here the authors reveal that the fusion transcription factor PAX3-FOXO1 shapes RNA Pol2 enhancer loops by recruitment of the histone acetyltransferase p300 via a small alpha-helical hook in its activation domain. Degradation of PAX3-FOXO1 or p300 rapidly collapses Pol2 clusters.

    • Yaw Asante
    • Katharina Benischke
    • Marco Wachtel
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • Autosomal recessive polycystic kidney disease (ARPKD) is a genetic disorder which is associated with kidney and liver pathology, including liver fibrosis. Here the authors develop and characterize human liver organoids with a ARPKD mutation, and find that they show aspects of the pathology, including fibrosis.

    • Yuan Guan
    • Annika Enejder
    • Gary Peltz
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15