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Showing 1–4 of 4 results
Advanced filters: Author: Iswar K. Hariharan Clear advanced filters

  • Plexins are semaphorin receptors and are well known for their roles in neuronal pathfinding. Here the authors describe a role for Plexin A in healing damaged epithelia in Drosophila and zebrafish. In Drosophila, Plexin A inhibits the GTPase Rap1 to allow epithelial remodelling to facilitate wound repair.

    • Sa Kan Yoo
    • Heath G. Pascoe
    • Iswar K. Hariharan
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • The kinase AMPK, a sensor of cellular energy stress, has been shown to oppose the growth-promoting activity of YAP, the transcriptional co-activator downstream of the Hippo signalling pathway. This finding may help to explain why the antidiabetic drug metformin, for which AMPK is a key effector, is linked to cancer-protective activity.

    • Iswar K. Hariharan
    News & Views
    Nature Cell Biology
    Volume: 17, P: 362-363

    • Iswar K. Hariharan
    Books & Arts
    Nature Cell Biology
    Volume: 6, P: 911